Gene therapy : therapeutic mechanisms and strategies / edited by Nancy Smyth Templeton, Danilo D. Lasic.

Format:

Book

Contributor:

Templeton, Nancy Smyth, 1952-

Lasic, Danilo D.

Language:

English

Subjects (All):

Gene therapy.

Genetic Therapy--methods.

Medical Subjects:

Genetic Therapy--methods.

Physical Description:

xv, 584 pages ; 29 cm

Place of Publication:

New York : Marcel Dekker, Inc., [2000]

Contents:

Part I. Viral Delivery and Therapeutic Strategies

1. Retroviral Vectors for Gene Therapy / Paula M. Cannon, W. French Anderson 1

2. Adenovirus Vectors for Gene Therapy / Neil R. Hackett, Ronald G. Crystal 17

3. Adeno-Associated Virus and Adeno-Associated Virus Vectors for Gene Delivery / Barrie J. Carter 41

4. Ex Vivo Gene Therapy Using Myoblasts and Regulatable Retroviral Vectors / Clare R. Ozawa, Matthew L. Springer, Helen M. Blau 61

5. Design and Use of Herpes Simplex Viral Vectors for Gene Therapy / Darren Wolfe, William F. Goins, David J. Fink, Joseph C. Glorioso, III 81

6. Alphavirus-Based Vectors for Vaccine and Gene Therapy Applications / Thomas W. Dubensky, Jr., John M. Polo, Douglas J. Jolly 109

Part II Nonviral Delivery and Therapeutic Strategies

7. Gene Delivery with Polyethylenimine / S. M. Zou, Jean-Paul Behr, D. Goula, Barbara Demeneix 131

8. Receptor-Mediated Gene Transfer / Kurosh Ameri, Ernst Wagner 141

9. Modification of Melanoma Cells via Ballistic Gene Delivery for Vaccination / Ulrich R. Hengge, Dirk Schadendorf 165

10. Polymer-Encapsulated Cells for Gene Therapy / Dwaine F. Emerich, Elizabeth Razee 181

11. Molecular Interactions in Lipids, DNA, and DNA-Lipid Complexes / Rudolf Podgornik, Helmut H. Strey, V. A. Parsegian 209

12. Bioorganic Colloids: Macromolecules, DNA, Self-Assembled Particles, and Their Complexes / Danilo D. Lasic, Nancy Smyth Templeton 241

13. Synthetic Virus Systems for Systemic Gene Therapy / Ian MacLachlan, Pieter Cullis, Roger W. Graham 267

Part III. Other Therapeutic Strategies and Regulatory Aspects

14. Gene Therapy Applications of Ribozymes / Bruce A. Sullenger, Lynn Milich 291

15. Antisense Oligonucleotide-Based Therapeutics / C. Frank Bennett, Madeline Butler, P. Dan Cook, Richard S. Geary, Arthur A. Levin, Rahul Mehta, Ching-Leou Teng, Hemant Deshmukh, Lloyd Tillman, Greg Hardee 305

16. Selectable Markers for Gene Therapy / Michael M. Gottesman, Thomas Licht, Yi Zhou, Caroline Lee, Tzipora Shoshani-Kupitz, Peter Hafkemeyer, Christine A. Hrycyna, Ira Pastan 333

17. Suicide Gene Therapy / Bert W. O'Malley, Jr. 353

18. Regulatory Aspects of Gene Therapy / Andra E. Miller, Stephanie L. Simek 371

Part IV. Disease Targets and Therapeutic Strategies

19. Gene Transfer into Hematopoietic Stem Cells / David M. Bodine 383

20. Gene Therapy for Hematopoietic Disorders / Mitchell E. Horwitz, Harry L. Malech 405

21. Gene Therapy for Cardiovascular Disease and Vascular Grafts / Afshin Ehsan, Michael J. Mann, Victor J. Dzau 421

22. Gene Therapy for Cancer / Karsten Brand, Gerhard Wolff, Michael Strauss 439

23. Barriers to Efficient Airway Epithelial Gene Transfer: Lessons from Cystic Fibrosis / Larry G. Johnson, Richard C. Boucher 473

24. Gene Transfer to the Central Nervous System / Ulrike Blomer, I. M. Verma, F. H. Gage 489

25. Principles of Gene Therapy for Inborn Errors of Metabolism / Jon A. Wolff, Cary O. Harding 507

26. Gene Therapy and HIV-1 Infection / Ralph Dornburg, Roger J. Pomerantz 519

27. Gene Delivery to the Skin / Paul A. Khavari 535

28. DNA Vaccines / Jong J. Kim, David B. Weiner 549.

Notes:

Includes bibliographical references and index.

ISBN:

0824776658

OCLC:

43854196