Angiogenesis : from the molecular to integrative pharmacology / edited by Michael E. Maragoudakis.

Format:

Book

Conference/Event

Contributor:

Maragoudakis, Michael E.

Conference Name:

International Meeting on Angiogenesis (5th : 1999 : Crete, Greece)

Series:

Advances in experimental medicine and biology ; v. 476.

Advances in experimental medicine and biology ; v. 476

Language:

English

Subjects (All):

Neovascularization--Congresses.

Neovascularization.

Neovascularization inhibitors--Congresses.

Neovascularization inhibitors.

Growth factors--Congresses.

Growth factors.

Angiogenesis Inducing Agents--physiology.

Cell Transformation, Neoplastic.

Neovascularization, Pathologic.

Neovascularization, Physiologic--drug effects.

Signal Transduction.

Medical Subjects:

Angiogenesis Inducing Agents--physiology.

Cell Transformation, Neoplastic.

Neovascularization, Pathologic.

Neovascularization, Physiologic--drug effects.

Signal Transduction.

Genre:

Conference papers and proceedings.

Physical Description:

x, 382 pages : illustrations ; 26 cm.

Place of Publication:

New York : Kluwer Academic/Plenum, [2000]

Summary:

Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece. Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field.

Contents:

Angiogenic Factors and Their Receptors

Examining New Models for the Study of Autocrine and Paracrine Mechanisms of Angiogenesis through FGF[subscript 2]-Transfected Endothelial and Tumour Cells / M. Presta, M. Rusnati, P. Dell'Era, E. Tanghetti, C. Urbinati, R. Giuliani, D. Leali 7

Tie-1 Receptor Tyrosine Kinase Endodomain Interaction with SHP2: Potential Signalling Mechanisms and Roles in Angiogenesis / M. Marron, D. Hughes, M. McCarthy, E. Beaumont, N. Brindle 35

On the Mechanism(s) of Thrombin Induced Angiogenesis / M.E. Maragoudakis, N.E. Tsopanoglou 47

Endothelial Receptor Tyrosine Kinases in Involved Blood Vessel Development and Tumor Angiogenesis / G. Breier 57

Ontogeny of the Endothelial System in the Avian Model / L. Pardanaud, F. Dieterlen-Lievre 67

Regulation of Angiogenesis and Transduction Mechanisms Involved

The Role of Pericytes in Controlling Angiogenesis In Vivo / S. Egginton, A-L. Zhou, M.D. Brown, O. Hudlicka 81

Insights into the Vasodilation of Rat Retinal Vessels Evoked by Vascular Endothelial Growth Factor[subscript 121] (VEGF[subscript 121]) / H.M. Hassessian 101

Signal Transduction and Transcriptional Regulation of Angiogenesis / Y. Sato, M. Abe, K. Tanaka, C. Iwasaka, N. Oda, S. Kanno, M. Oikawa, T. Nakano, T. Igarashi 109

Differential Contribution of Bradykinin Receptors in Angiogenesis / L. Morbidelli, A. Parenti, S. Donnini, H. Granger, F. Ledda, M. Ziche 117

Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Breakdown in VEGF Transgenic Mice / S.A. Vinores, N.L. Derevjanik, M.A. Vinores, N. Okamoto, P.A. Campochiaro 129

Revascularization of Ischemic Tissues with SIKVAV and Neuropeptide Y (NPY) / D.S. Grant, Z. Zukowska 139

Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor, Protein S, in Vascular Cells / C. Kanthou, O. Benzakour 155

Role of Extracellular Matrix and Adhesion Molecules in Angiogenesis

Targeting Integrins a[subscript v]b[subscript 3] and a[subscript v]b[subscript 5] for Blocking Tumor-Induced-Angiogenesis / C. Kumar, L. Armstrong, Z. Yin, M. Malkowski, E. Maxwell, He. Ling, B. Yaremko, M. Liu., J. Varner, E.M. Smith, B. Neustadt, T. Nechuta 169

Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis with Synthetic Matrixin Inhibitors / M-C Jia, M.A. Schwartz, Q.X. Sang 181

Inhibitors of Angiogenesis and Their Mechanisms of Action

Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by Inducing Apoptosis / J.A. Martinez, I. Torres-Negron, L.A. Amigo, R.A. Roldan, A. Mendez, D.K. Banerjee 197

The Characterization of Angiogenesis Inhibitor from Shark Cartilage / J. H. Liang, K.P. Wong 209

Quantitative Assays for the Chick Chorioallantoic Membrane / D.W. Thompson, A. Reid 225

Angiogenesis and Malignant Transformation

MYCN Oncogene and Angiogenesis: Down-Regulation of Endothelial Growth Inhibitors in Human Neuroblastoma Cell / E. Hatzi, S. Breit, A. Zoephel, K. Ashman, U. Tontsch, H. Aborn, C. Murphy, L. Schweigerer, Th. Fotsis 239

From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the Colorectal Adenoma - Carcinoma Model / L. Kaklamanis, S. Kakolyris, M. Koukourakis, K. Gatter, A. Harris 249

Tumor Angiogenesis, Macrophages, and Cytokines / H. Bando, M. Toi 267

Microvessel Density, Thymidine Phosphorylase Expression, and Resistance of Head and Neck Cancer to Chemo-Radiotherapy / M. Koukourakis 285

Differential Expression of Angiogenic and of Vascular Survival Factors in Non-Small Cell Lung Cancer (NSCLC) / A. Gatromanolaki 291

Thymidine Phosphorylase Activity in Normal, Hyperplastic and Neoplastic Endometrium

Correlation with Intratumoral Angiogenesis / E. Sivridis 297

Preclinical Developments of Angiogenesis Inhibitors

Inhibition of VEGF Signal Transduction / S. Wedge, D. Ogilvie 307

Combretastatins: Novel Vascular Targeting Drugs for Improving Anti-Cancer Therapy / M. Horsman, R. Murata, T. Breidahl, F. Nielsen, R. Maxwell, H. Stokilde-Jorgensen, J. Overgaard 311

Clinical Applications

Therapeutic Angiogenesis for Ischemic Heart Disease / A. Helisch, J.A. Ware 327.

Notes:

"Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece"--T.p. verso.

Includes bibliographical references and index.

ISBN:

030646375X

OCLC:

43442031