Endocrinology of the lung : development and surfactant synthesis / edited by Carole R. Mendelson.

Format:

Book

Contributor:

Mendelson, Carole R.

Series:

Contemporary endocrinology (Totowa, N.J.)

Contemporary endocrinology

Language:

English

Subjects (All):

Lungs--Growth.

Lungs--Diseases--Endocrine aspects.

Lung--growth & development.

Lung Diseases.

Endocrinology.

Lungs--Diseases.

Lungs.

Medical Subjects:

Lung--growth & development.

Lung Diseases.

Endocrinology.

Physical Description:

x, 344 pages : illustrations (some color) ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, 2000.

Summary:

Carole Mendelson has assembled a panel of leading investigators to critically review the various classes of endocrine, paracrine, and neuroendocrine factors that play a role in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung development and the synthesis of surfactant glycerophospholipids and proteins. Also extensively treated are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for all those actively investigating hormone action in pulmonary biology and medicine today.

Contents:

1 The Glucocorticoid Domain in the Lung and Mechanisms of Action / Philip L. Ballard 1

2 Fetal Responses to Glucocorticoids / Alan H. Jobe, Machiko Ikegami 45

3 Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression / Carole R. Mendelson, Laura F. Michael, Pampee P. Young, Jinxing Li, Joseph L. Alcorn 59

4 Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung / Vijayakumar Boggaram 81

5 Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung / Seamus A. Rooney 91

6 The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis: A First Approximation of the Epigenetic Rules / Tina Jaskoll, Michael Melnick 105

7 Corticotropin-Releasing Hormone and the Lung / Maria Venihaki, Louis J. Muglia, Joseph A. Majzoub 125

8 Sex Differences in Fetal Lung Development: Biology, Etiology, and Evolutionary Significance / Heber C. Nielsen, John S. Torday 141

9 Retinoids and Lung Development / Richard D. Zachman, Mary A. Grummer 161

10 Insulin and Lung Development / Jeanne M. Snyder, Thomas N. George, Olga L. Miakotina 181

11 The Insulin-like Growth Factor System and Lung / Wayne A. Price, Alan D. Stiles 201

12 Platelet-Derived Growth Factor and Lung Development / Nicholas J. Cartel, Martin Post 225

13 Transforming Growth Factor-[beta] Receptor Signaling and Lung Development / Yun Zhao 241

14 Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis / Jeffrey A. Whitsett, Thomas R. Korfhagen 255

15 Parathyroid Hormone-Related Protein / Lewis P. Rubin, John S. Torday 269

16 Role of Neuroendocrine Cells in Fetal and Postnatal Lung / Mary E. Sunday, Ernest Cutz 299.

Notes:

Includes bibliographical references and index.

ISBN:

0896036766

OCLC:

42810651