Molecular mechanisms of negative selection in immature B cells / Peter Christian Sandel.

Format:

Book

Manuscript

Microformat

Thesis/Dissertation

Author/Creator:

Sandel, Peter Christian.

Contributor:

Monroe, John G., advisor.

University of Pennsylvania.

Language:

English

Subjects (All):

Penn dissertations--Immunology.

Immunology--Penn dissertations.

Allergy and Immunology.

Academic Dissertations as Topic.

Medical Subjects:

Allergy and Immunology.

Academic Dissertations as Topic.

Local Subjects:

Penn dissertations--Immunology.

Immunology--Penn dissertations.

Physical Description:

x, 176 pages : illustrations (some color) ; 29 cm

Production:

1999.

Summary:

Immature B cells that encounter self-antigen are eliminated from the immune repertoire by a process termed negative selection. Negative selection has been proposed to take place by three district mechanisms: deletion by apoptosis, induction of anergy or alteration of the antigen receptor specificity by receptor editing. While convincing evidence exists for each, these models are inherently contradictory. In this thesis, we propose a resolution to this contradiction by demonstrating that the site of first antigen encounter dictates which mechanism of negative selection is utilized. Immature B cells that encounter self antigens in the bone marrow are not deleted but are protected from B cell antigen receptor (BCR) induced apoptosis by a Thy-1.2dull DX5+ bone marrow NK-like cell and are induced to edit their antigen receptors. This is in contrast to transitional immature B cells that encounter self-antigens in the periphery are signaled to undergo apoptosis and are thus deleted from the immune repertoire.

Notes:

Adviser: John G. Monroe.

Thesis (Ph.D. in Immunology) -- University of Pennsylvania, 1999.

Includes bibliographical references.

Local Notes:

University Microfilms order no.: 99-53589.

OCLC:

187484035