Signaling networks and cell cycle control : the molecular basis of cancer and other diseases / edited by J. Silvio Gutkind.

Format:

• Book

Contributor:

• Gutkind, J. Silvio.

Series:

• Cancer drug discovery and development

Language:

English

Subjects (All):

• Cellular signal transduction.
• Cell cycle.
• Cellular control mechanisms.
• Pathology, Molecular.

Physical Description:

xiv, 578 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2000]

Summary:

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Contents:

• 1 Integrin Signaling / Kenneth M. Yamada, Erik H. J. Danen 1
• 2 Signal Transduction Through Tyrosine Kinase Growth Factor Receptors / Paolo Fedi, Stuart A. Aaronson 27
• 3 Signaling from TGF-[beta] Receptors / Anita B. Roberts, Mark P. de Caestecker, Robert J. Lechleider 39
• 4 The Wnt Signal Transduction Pathway / Grant D. Barish, Bart O. Williams 53
• 5 Signaling from G-Protein-Coupled Receptors to the Nucleus / Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, J. Silvio Gutkind 83
• 6 Proximal Events in T-Cell Activation / Joanne Sloan-Lancaster, Lawrence E. Samelson 99
• 7 Signal Transduction from the High Affinity IgE Receptor / Reuben P. Siraganian 113
• 8 Signaling Through Fas (CD95, APO-1) and Related Death Receptors / Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, Michael J. Lenardo 135
• 9 Signal Transduction to the Nucleus by MAP Kinase / Roger J. Davis 153
• 10 The Regulation of MAP Kinase Pathways by MAP Kinase Phosphatases / Kathleen Kelly, Yanfang Chu 165
• 11 Control of MAPK Signaling by Ste20- and Ste11-Like Kinases / Gary R. Fanger, Thomas K. Schlesinger, Gary L. Johnson 183
• 12 Ras Signaling and Transformation / Geoffrey J. Clark, John P. O'Bryan, Channing J. Der 213
• 13 Signaling Pathways Controlled by Rho Family GTP-Binding Proteins / Marc Symons 231
• 14 PI3-Kinases: Role in Signal Transduction / David A. Fruman, Lewis C. Cantley 247
• 15 PI3K-Related Kinases: Roles in Cell-Cycle Regulation and DNA Damage Responses / Randal S. Tibbetts, Robert T. Abraham 267
• 16 Integrative Signaling Through c-Abl: A Tyrosine Kinase with Nuclear and Cytoplasmic Functions / Jean Y. J. Wang 303
• 17 Src: A Model for Regulation of Intracellular Signaling Molecules / Pamela L. Schwartzberg 325
• 18 Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second Messenger sn-1,2-Diacylglycerol / Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, Patricia S. Lorenzo 347
• 19 Reactive Oxygen Species in Proliferative Signaling / Toren Finkel, Daniel M. Sullivan 365
• 20 Sphingolipid Metabolites in Signal Transduction / Sarah Spiegel, Sheldon Milstien 379
• 21 The Jak/Stat Signaling Cascade: Its Role in the Biological Effects of Interferons / Andrew C. Larner, Andrew Keightley 393
• 22 Regulation of Cell Growth and Death by p53 / Kevin M. Ryan, Karen H. Vousden 411
• 23 Regulation of NF-[kappa]B Function: Novel Molecular Targets for Pharmacological Intervention / Frank Mercurio, Anthony M. Manning 429
• 24 Using Protein-Interaction Domains to Manipulate Signaling Pathways / Bruce J. Mayer 439
• 25 Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents / Alexander Levitzki 453
• 26 A Pharmacological Approach to the MAP Kinase Cascade / David T. Dudley, Alan R. Saltiel 467
• 27 Specific Inhibitors of p38 MAP Kinase / Peter R. Young 483
• 28 Farnesyltransferase Inhibitors: Anti-Ras or Anticancer Drugs? / Adrienne D. Cox, Channing J. Der 501
• 29 Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization / Esther H. Chang, Liang Xu, Kathleen F. Pirollo 519
• 30 Treatment of p53-Deficient Cancers by Adenovirus E1B-Region Mutants: From Basic Research to the Clinic / David H. Kirn 537
• 31 The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention / Michele Pagano, Katya Ravid 545
• 32 Chemical Cyclin-Dependent Kinase Inhibitors: Therapeutic Implications / Edward A. Sausville, Adrian M. Senderowicz 557.

Notes:

Includes bibliographical references and index.

ISBN:

089603710X

OCLC:

42761720