Medical cytogenetics / edited by Hon Fong L. Mark.

Format:

Book

Contributor:

Mark, Hon Fong L., 1948-

Patrick B. and Anne Gaydosh Hughes Memorial Book Fund.

Language:

English

Subjects (All):

Cytogenetics--methods.

Chromosome Aberrations--diagnosis.

Genetic Testing.

Genetic Techniques.

Neoplasms--diagnosis.

Medical Subjects:

Cytogenetics--methods.

Chromosome Aberrations--diagnosis.

Genetic Testing.

Genetic Techniques.

Neoplasms--diagnosis.

Physical Description:

xvii, 680 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2000]

Summary:

The only monograph on cytogenetics for the pathologist, this up-to-the-minute reference/text contains the most up-to-date research findings on many important topics in medical genetics-notably FISH (fluorescent in situ hybridation)-based molecular cytogenetic technologies and spectral karyotyping. An excellent resource for cytogeneticists preparing for the certifying examination in Clinical Cytogenetics offered by the American Board of Medical Genetics (ABMG). Written by nearly 30 distinguished international contributors, Medical Cytogenetics covers the history of the field, tissue culturing and staining techniques, and clinical applications of FISH, as well as other methods for genetic studies and chromosomal analysis supplies numerous examples and case reports examines reproductive dysfunctions such as in-utero abnormalities, male infertility, and failure to conceive investigates chromosomal abnormalities associated with myeloid hematopoietic disorders, lymphoid neoplasms, and solid tumors such as those associated with breast cancer reviews means of obtaining accreditation or licenses, use of external peer reviews and voluntary inspections, proficiency testing, and regulatory oversight and more! Thoroughly referenced with over 1800 bibliographic citations, and supplemented with a useful glossary, a large number of practice questions, and over 40 color photographs, Medical Cytogenetics is a pragmatic, hands-on reference for pathologists, geneticists, cytogenetic technologists, molecular and cell biologists, clinical and medical oncologists, hematologists, neurologists, pediatricians, endocrinologists, obstetricians, gynecologists, and primary care physicians, and an exceptional text for upper-level undergraduate, graduate, and medical students in these disciplines.

Contents:

1 Cytogenetics as a Specialty of Medical Genetics / Hon Fong L. Mark, Reed E. Pyeritz 1

2 The Normal Human Chromosome Complement / Hon Fong L. Mark, Yvonne Mark 21

3 Human Cytogenetic Nomenclature / Sugandhi A. Tharapel, Avirachan T. Tharapel 49

4 Culture and Harvest of Tissues for Chromosome Analysis / Hon Fong L. Mark, Sandra R. Wolman 91

5 Staining and Banding Techniques for Conventional Cytogenetic Studies / Hon Fong L. Mark 121

6 Fluorescent In Situ Hybidization (FISH): Principles and Methodology / Jan K. Blancato, Bassem R. Haddad 141

7 Cytogenetics in Medicine / Bruce R. Korf, Nancy R. Schneider 165

8 Prenatal Chromosome Diagnosis / Allen N. Lamb, Wayne A. Miller 191

9 Cytogenetics of Reproductive Wastage: From Conception to Birth / Dorothy Warburton 213

10 Cytogenetics of Male Infertility / Hon Fong L. Mark, Mark Sigman 247

11 Recurring Cytogenetic Abnormalities in the Myeloid Hematopoietic Disorders / John Anastasi, Diane Roulston 275

12 Cytogenetics of Lymphoid Neoplasias / Susana C. Raimondi 349

13 Chromosome Abnormalities in Solid Tumors: An Overview / Avery A. Sandberg, Zhong Chen 413

14 Chromosome Instability and Fragile Sites / Herman E. Wyandt, Vijay S. Tonk, Roger V. Lebo 437

15 Cytogenetics of Breast Cancer / Sandra R. Wolman 511

16 Cytogenetics in Transfusion Medicine / Carolyn Te Young, Hon Fong L. Mark 537

17 Fluorescent In Situ Hybridization (FISH): Applications for Clinical Cytogenetics Laboratories / Hon Fong L. Mark 553

18 Evolving Molecular Cytogenetic Technologies / Gabriela Adelt Green, Evelin Schrock, Kerstin Heselmeyer-Haddad, Tim Veldman, Hesed M. Padilla-Nash, Thomas Ried 579

19 Preanalytical Variables in Cytogenetic Studies / Jila Khorsand 593

20 Setting the Standards for Cytogenetic Laboratories / Gerald A. Hoeltge 607.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Patrick B. and Anne Gaydosh Hughes Memorial Book Fund.

ISBN:

0824719999

OCLC:

43523143