Nitric oxide and the cardiovascular system / edited by Joseph Loscalzo, Joseph A. Vita.

Format:

Book

Contributor:

Loscalzo, Joseph.

Vita, Joseph A.

Series:

Contemporary cardiology (Totowa, N.J.)

Contemporary cardiology

Language:

English

Subjects (All):

Cardiovascular system--Pathophysiology.

Cardiovascular system.

Nitric oxide--Physiological effect.

Nitric oxide.

Cardiovascular System--physiopathology.

Nitric Oxide--physiology.

Medical Subjects:

Cardiovascular System--physiopathology.

Nitric Oxide--physiology.

Physical Description:

xi, 601 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2000]

Summary:

Interest in nitric oxide biology has greatly intensified over the past decade in concert with our increasing appreciation of its many roles in the cardiovascular system. In Nitric Oxide and the Cardiovascular System, world leaders in the field comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in cardiovascular health and disease. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine.

With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Contents:

Part I Biology of Nitric Oxide 1

1 The Biological Chemistry of Nitric Oxide / Joseph Loscalzo 3

2 Cell and Molecular Biology of Nitric Oxide Synthases / Olivier Feron, Thomas Michel 11

3 Cellular Signal Transduction and Nitric Oxide / Stanley Heydrick 33

4 Regulation of Gene Expression by Nitric Oxide / Ami A. Deora, Harry M. Lander 51

5 Cytotoxicity, Apoptosis, and Nitric Oxide / Stefanie Dimmeler, Andreas M. Zeiher 69

6 Nitric Oxide and Ion Channels / Victoria M. Bolotina 85

7 Role of Nitric Oxide in Vasomotor Regulation / Richard A. Cohen 105

8 Nitric Oxide and Platelet-Mediated Hemostasis / Elisabeth M. Battinelli, Joseph Loscalzo 123

9 Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion / Wolfgang Cerwinka, D. Neil Granger 139

10 Nitric Oxide and Cardiomyocyte Function / Jean-Luc Balligand, Paul J. Cannon 153

11 The Fibroblast and Nitric Oxide / Peter Brecher 177

12 Nitric Oxide in Cardiac Electrophysiology / Lu Fei, Douglas P. Zipes 191

Part II Cardiovascular Pathophysiology of Nitric Oxide 205

13 Nitric Oxide and Endothelial Dysfunction / Gerard A. Dillon, Joseph A. Vita 207

14 Nitric Oxide and Hypertension / M. Audrey Rudd, Maria R. Trolliet, Joseph Loscalzo 227

15 Nitric Oxide and Pulmonary Hypertension / John J. Leopore, Kenneth D. Bloch 247

16 Nitric Oxide in Atherosclerosis / Robert T. Eberhardt, Joseph Loscalzo 273

17 Thrombotic Disorders and Nitric Oxide Insufficiency / Jane E. Freedman, Joseph Loscalzo 297

18 Myocardial Nitric Oxide in Heart Failure / Douglas B. Sawyer, Wilson S. Colucci 309

19 Shock States and Nitric Oxide / Hartmut Ruetten, Christoph Thiemermann 321

20 Stroke and Nitric Oxide / Nancy E. Stagliano, Paul L. Huang 343

21 The Role of Nitric Oxide in Ischemia-Reperfusion / Allan M. Lefer, Reid Hayward 357

Part III Nitric Oxide in Cardiovascular Therapeutics 381

22 Nitrovasodilators / John D. Horowitz 383

23 S-Nitrosothiols / Jane A. Leopold, Joseph Loscalzo 411

24 Diazeniumdiolates (Formerly NONOates) in Cardiovascular Research and Potential Clinical Applications / Joseph E. Saavedra, Anthony L. Fitzhugh, Larry K. Keefer 431

25 Inhaled Nitric Oxide Therapy for Acute Respiratory Failure / William Hurford, Warren M. Zapol 447

26 Antioxidants and Endothelium-Derived Nitric Oxide Action / Annong Huang, John F. Keaney, Jr. 473

27 Coating Arterial and Blood-Contacting Surfaces with NO-Donating Compounds / John D. Folts, Joseph Loscalzo 503

28 Gene Therapy and Nitric Oxide / Heiko E. von der Leyen 515

29 Nitric Oxide and Tissue Preservation in Transplantation / David J. Pinsky, David M. Stern 529

30 L-Arginine: Its Role in Cardiovascular Therapy / Andrew J. Maxwell, John P. Cooke 547.

Notes:

Includes bibliographical references and index.

ISBN:

0896036200

OCLC:

42683311