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Central nervous system diseases : innovative animal models from lab to clinic / edited by Dwaine F. Emerich, Reginald L. Dean, III, Paul R. Sanberg.
Holman Biotech Commons RC361 .C44 2000
Available
- Format:
- Book
- Series:
- Contemporary neuroscience
- Language:
- English
- Subjects (All):
- Animal models.
- Central nervous system--Diseases--Animal models.
- Central nervous system.
- Alzheimer Disease--physiopathology.
- Aging--physiology.
- Huntington Disease--physiopathology.
- Models, Biological.
- Parkinson Disease--physiopathology.
- Huntington's disease--Pathophysiology.
- Huntington's disease.
- Alzheimer's disease--Pathophysiology.
- Alzheimer's disease.
- Aging--Physiological aspects.
- Aging.
- Biological models.
- Physiology, Pathological.
- Central nervous system--Diseases.
- Medical Subjects:
- Alzheimer Disease--physiopathology.
- Aging--physiology.
- Huntington Disease--physiopathology.
- Models, Biological.
- Parkinson Disease--physiopathology.
- Physical Description:
- xv, 512 pages : illustrations ; 26 cm.
- Place of Publication:
- Totowa, N.J. : Humana Press, [2000]
- Summary:
- Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
- Contents:
- Part I. Aging and Alzheimer's Disease
- 1 The Cholinergic Hypothesis a Generation Later: Perspectives Gained on the Use and Integration of Animal Models / Raymond T. Bartus 3
- 2 Patterns of Cognitive Decline in the Aged Rhesus Monkey / Mark B. Moss, Ronald J. Killiany, James G. Herndon 47
- 3 Cholinergic Lesions as a Model of Alzheimer's Disease: Effects of Nerve Growth Factor / James M. Conner, Mark H. Tuszynski 65
- 4 The Immunolesioned Animal as a Model of Transmitter Dysfunction / Gary L. Wenk 81
- 5 An Intracerebral Tumor Necrosis Factor-[alpha] Infusion Model for Inflammation in Alzheimer's Disease / Kimberly B. Bjugstad, Gary W. Arendash 93
- 6 The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia / Yasuyuki Nomura, Yasunobu Okuma, Yoshihisa Kitamura 113
- 7 Transgenic Mice Overexpressing Presenilin cDNAs: Phenotype and Utility in the Modeling of Alzheimer's Disease / Karen Duff 123
- Part II. Parkinson's Disease
- 8 Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism: Optimizing Behavioral Assessment of Outcome / Timothy Schallert, Jennifer L. Tillerson 131
- 9 Development of Behavioral Outcome Measures for Preclinical Parkinson's Research / Mark D. Lindner 153
- 10 Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset / L. E. Annett, R. E. Smyly, J. M. Henderson, R. M. Cummings, A. L. Kendall, S. B. Dunnett 171
- 11 Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson's Disease / O. Isacson, L. C. Costantini, W. R. Galpern 187
- 12 Antisense Knockdown of Dopamine Receptors / Simranjit Kaur, Ian Creese 209
- 13 Is Trophic Factor Gene Disruption a "Knockout" Model for Parkinson's Disease? / Ann-Charlotte Granholm, Barry Hoffer 227
- Part III. Huntington's Disease
- 14 Operant Analysis of Striatal Dysfunction / Peter J. Brasted, Mate D. Dobrossy, Dawn M. Eagle, Falguni Nathwani, Trevor W. Robbins, Stephen B. Dunnett 249
- 15 Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington's Disease / Dwaine F. Emerich 275
- 16 Systemic Administration of 3-Nitropropionic Acid: A New Model of Huntington's Disease in Rat / Emmanuel Brouillet, Philippe Hantraye, M. Flint Beal 301
- 17 Replicating Huntington Disease's Phenotype in Nonhuman Primates / Philippe Hantraye, Stephane Palfi, Vincent Mittoux, Caroline Dautry, Francoise Conde, Emmanuel Brouillet 333
- 18 Transgenic Mouse Models of Huntington's Disease / Gillian P. Bates, Laura Mangiarini, Stephen W. Davies 355
- Part IV. Traumatic Brain Injury and Stroke
- 19 Rigid Indentation Models of Traumatic Brain Injury in the Rat / Richard L. Sutton 371
- 20 Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery: Clinical Relevance to Treatment Strategies of Stroke / Cesario V. Borlongan, Hitoo Nishino, Yun Wang, Paul R. Sanberg 393
- 21 A Primate Model of Hypertensive Cerebrovascular Disease / Mark B. Moss 407
- Part V. Innovations Leading to Clinical Therapy
- 22 Nictotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders: From Laboratory to Clinic / R. Doug Shytle, Archie A. Silver, Mary B. Newman, Paul R. Sanberg 431
- 23 Neural Grafting for Parkinson's and Huntington's Disease / Ben Roitberg, Peter Shin, Joseph Sramek, Jeffrey H. Kordower 441
- 24 Future Prospects of Gene Therapy for Treating CNS Diseases / Daniel A. Peterson, Jasodhara Ray, Fred H. Gage 485.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 089603724X
- OCLC:
- 41096195
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