Current controversies in bone marrow transplantation / edited by Brian J. Bolwell.

Format:

Book

Contributor:

Bolwell, Brian J.

Series:

Current clinical oncology

Language:

English

Subjects (All):

Hematopoietic stem cells--Transplantation.

Hematopoietic stem cells.

Cancer--Immunotherapy.

Cancer.

Bone marrow--Transplantation.

Bone marrow.

Neoplasms--therapy.

Bone Marrow Transplantation.

Hematopoietic Stem Cell Transplantation.

Medical Subjects:

Neoplasms--therapy.

Bone Marrow Transplantation.

Hematopoietic Stem Cell Transplantation.

Physical Description:

xiv, 322 pages : illustrations ; 27 cm.

Place of Publication:

Totowa,N.J. : Humana Press, [2000]

Summary:

Leading transplant physicians critically review and interpret twenty-one key clinical challenges in bone marrow/hematopoietic cell transplantation, and offer their best personal recommendations for treatment. Topics range from transplant strategies to complications of bone marrow transplantation, including a discussion of the indications, benefits, and the risks for a variety of leukemias, lymphomas, and solid tumors. The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, and the pros and cons of umbilical cord blood transplantation. Up-to-date and clinically focused, Current Controversies in Bone Marrow Transplantation offers clinical oncologists, hematology/oncology fellows in training, and residents in internal medicine today's best ready reference and management guide for all their critical oncologic problems arising from the use of bone marrow/stem cell transplantation.

Contents:

Part I. Transplant Strategies

1 How Many Stem Cells Are Sufficient for Engraftment? / Lynn C. O'Donnell, PHD, Patrick J. Elder, MS, Belinda R. Avalos, MD 3

2 Is Bone Marrow Transplantation Appropriate in Older Patients? / Brian J. Bolwell, MD 29

3 What Is an Accurate Risk/Benefit Ratio for Umbilical Cord Cell Transplantation in Children and Adults? / Mary J. Laughlin, MD 41

4 Are Busulfan-Based Preparative Regimens Equivalent, Worse, or Better than Total Body Irradiation Regimens? / Edward A. Copelan, MD 53

5 Is Total Body Irradiation Necessary in Bone Marrow Transplantation for Pediatric ALL? / Susan R. Wiersma, MD, Susan B. Shurin, MD 69

Part II. Transplantation for Hematologic Malignancies

6 Stem Cell Transplantation for Chronic Myeloid Leukemia: Indications and Timing / Michael R. Bishop, MD 83

7 Should All Adult Patients with Acute Lymphoblastic Leukemia in First Remission Undergo Allogeneic Bone Marrow Transplantation? / Sam L. Penza, MD, Edward A. Copelan, MD 95

8 What Is the Curative Potential of Refractory Leukemia with Related and Unrelated Allogeneic Transplants? / Matt E. Kalaycio, MD 107

9 What Is the Role of Autologous Stem Cell Transplantation for Leukemia? / Selina M. Luger, MD, Edward A. Stadtmauer, MD 119

10 Autologous Transplantation for Hodgkin's Disease: Who Benefits? / Craig H. Moskowitz, MD, Stephen D. Nimer, MD 137

11 Hematopoietic Stem Cell Transplantation for Mantle Cell Lymphoma / Brad Pohlman, MD 147

12 Is Autologous Transplantation for Non-Hodgkin's Lymphoma Underutilized? / Brian J. Bolwell, MD 161

Part III. Transplantation for Solid Tumors

13 Do Patients Benefit from Autotransplants for Advanced Ovarian Cancer? / Janet Ruzich, DO, Patrick J. Stiff, MD 177

14 What Is the Optimal Timing of Autologous Transplantation for Metastatic Breast Cancer? / Stephanie F. Williams, MD 191

15 Should All Patients with Inflammatory Breast Cancer Undergo Autologous Stem Cell Transplant? / Beth A. Overmoyer, MD 199

16 High-Dose Chemotherapy with Stem Cell Rescue for Germ Cell Cancer? / E. Randolph Broun, MD 217

Part IV. Complications of Transplantation

17 Graft-vs-Host Disease: Has Any Progress Been Made in the Past Decade? / Thomas R. Spitzer, MD, Robert Sackstein, MD, PHD 229

18 Veno-occlusive Disease of the Liver: Does Anything Really Work? / Scott I. Bearman, MD 249

19 Myelodysplasia and Acute Leukemia Following High-Dose Chemotherapy / Dean S. McGaughey, MD, James J. Vredenburgh, MD 261

20 Can Aspergillus Infections Be Prevented in Allogeneic Bone Marrow Transplant Recipients? / Sherif B. Mossad, MD, David L. Longworth, MD 279

21 Prevention of Cytomegalovirus Infection After Allogeneic Bone Marrow Transplantation / Karim A. Adal, MD, Robin K. Avery, MD 295.

Notes:

Includes bibliographical references and index.

ISBN:

0896037827