High-dose cancer therapy : pharmacology, hematopoietins, stem cells / editors, James O. Armitage, Karen H. Antman.

Format:

Book

Contributor:

Armitage, James O., 1946-

Antman, Karen.

Language:

English

Subjects (All):

Cancer--Chemotherapy.

Cancer.

Cancer--Chemotherapy--Complications--Prevention.

Drugs--Dosage.

Drugs.

Hematopoietic growth factors--Therapeutic use.

Hematopoietic growth factors.

Neoplasms--drug therapy.

Antineoplastic Agents--pharmacology.

Dose-Response Relationship, Drug.

Hematopoietic Cell Growth Factors--therapeutic use.

Cancer--Chemotherapy--Complications.

Medical Subjects:

Neoplasms--drug therapy.

Antineoplastic Agents--pharmacology.

Dose-Response Relationship, Drug.

Hematopoietic Cell Growth Factors--therapeutic use.

Physical Description:

xxii, 951 pages, 2 unnumbered pages of plates : illustrations (some color) ; 26 cm

Edition:

Third edition.

Place of Publication:

Philadelphia : Lippincott Williams & Wilkins, 2000.

Summary:

This reflects the fact that this treatment modality is now the standard of care for a variety of cancers, including 10-20,000 cases/year of various forms of leukemia, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, ovarian cancer, etc. High-dosage chemotherapy is now also used in advanced cases of breast cancer. It is now being done by private practitioners in most of the hospitals in the country from the community hospital on up.

Contents:

Section I Strategies for the Use of Agents at High Dose

1. Pharmacologic Strategies for High-Dose Therapy / O. Michael Colvin, William Petros 3

2. Preclinical Models for High-Dose Therapy / Beverly A. Teicher 15

3. Pharmacokinetics / Roy B. Jones, Steven Matthes, Pablo J. Cagnoni 49

4. What Is the Best Strategy for Autologus Hematopoietic Stem Cell Transplantation in Cancer? / Gordon L. Phillips 69

5. Strategies for the Use of Total-Body Irradiation as Stemic Therapy in Hematologic Malignancies / Joachim Yahalom 77

6. Radioimmunotherapy / Mark S. Kaminski 109

7. Immune Adjuvant Therapy Post High-Dose Therapy / Shimon Slavin, Arnon Nagler 123

8. A Health Policy Perspective on High-Dose Cancer Therapy: Cost, Effectiveness, and Cost-Effectiveness / Charles L. Bennett, Tammy J. Stinson 139

9. Quality of Life after Bone Marrow Transplantation / Craig A. Bunnell, Caryn Silver, Eric P. Winer 153

10. Gene Therapy / Arthur Bank 167

Section II Reestablishing Hematopoiesis after Dose-Intensive Therapy Transplantation

11. The Hematopoietic Microenvironment / Stephen G. Emerson, Scott Adams, Russell Taichman 185

12. Hematologic Reconstitution after Allogeneic Hematopoietic Cell Transplantation / Laura J. Johnston, Karl G. Blume 193

13. Allogeneic Core Blood Hematopoietic Stem Cell Transplants in Malignancies / Eliane Gluckman, Vanderson Rocha, Claude Chastang 211

14. Bone Marrow Transplantation Using Unrelated Donors / Mary M. Horowitz, Craig W.S. Howe 221

15. Autologous Bone Marrow Transplantation / Armand Keating 243

16. Reestablishing Hematopoiesis with Peripheral Stem Cells / Anne Kessinger 273

17. Immunologic Reconstitution after High-Dose Chemoradiotherapy and Allogeneic of Autologus Bone Marrow or Peripheral Blood Hematopoietic Stem Cell Transplantation / Robert P. Witherspoon 283

Marrow Contamination

18. Minimal Disease: Detection and Significance / J. Graham Sharp 301

19. Negative and Positive Stem Cell Selection / Susan Roman-Unfer, Brett Cook, Yago Nieto, Elizabeth J. Shpall 331

20. Stem Cell In Vitro Purging for Autologous Transplantation / N. Claude Gorin 355

Growth Factors

21. Granulocyte-Macrophage Colony-Stimulating Factor / Richard G. Ghalie, Martin S. Tallman 393

22. Recombinant Human Granulocyte Colony-Stimulating Factor Support of Cancer Patient / Jeffrey Crawford, Michael E. Lee 411

23. Erythropoietin / Carole B. Miller 437

24. The Biology and Clinical Use of Stem Cell Factor / Rajesh Chopra, J. Howard Scarffe 455

25. Other Cytokines (IL-11, Thrombopoietin, flt-3 Ligand, and IL-3) / Julie M. Vose 467

Section III Laboratory and Clinical Support for Dose-Intensive Therapy

26. The American Society of Clinical Oncology and American Society of Hematology Recommended Criteria for the Performance of Bone Marrow Transplantation 479

27. Nursing for Patients Receiving High-Dose Chemotherapy with Hematopoietic Rescue / Elizabeth C. Reed, Theres a Franco 481

28. Line Maintenance / James R. Gould 495

29. Blood Bank Support for Patients Undergoing High-Dose Chemotherapy / George D. Demetri, Kenneth C. Anderson 511

30. Infectious Complications after High-Dose Chemotherapy / Omrum Uzun, Emin Kansu, Keith M. Sullivan 535

31. Pulmonary Complications / Joseph H. Sisson, Linda C. Anderson, Anthony A. Floreani, Stephen I. Rennard, Debra J. Romberger, Austin B. Thompson III, Susanna G. Von Essen 557

32. Hepatic Complications of Bone Marrow Transplantation / Lois J. Ayash 575

33. Cardiovascular System and High-Dose Therapy / Kevin M. Mulhern, David J. Skorton 595

34. Multiple Organ Dysfunction Syndrome / William D. Haire 609

35. Dermatology / Kristie D. Hayes 625

36. Genitourinary, Gastrointestinal, Endocrine, Nervous System, and Coagulation Complications / Michael C. Perry 641

37. Gonadal Complications / Catherine E. Klein 649

Section IV Clinical Applications of High-Dose Therapy

38. High-Dose Therapy in Acute Myeloid Leukemia / Alan K. Burnett 667

39. High-Dose Therapy in Acute Lymphoblastic Leukemia / Lewis B. Silverman, Amy L. Billett 691

40. Chronic Myelogenous Leukemia / David G. Savage, John M. Goldman 705

41. Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia / Issa F. Khouri, Michael J. Keating, Richard E. Champlin 733

42. High-Dose Therapy in Multiple Myeloma / Michel Attal, Jean-Luc Harousseau 743

43. High-Dose Therapy for Hodgkin's Disease / Philip J. Bierman, James O. Armitage 755

44. High-Dose Therapy for the Treatment of Non-Hodgkin's Lymphoma / Ron K. Chakraverty, Anthony H. Goldstone, Andrew K. McMillan, Rajesh Chopra 775

45. High-Dose Therapy in Burkitt's Lymphoma / Jean-Yves Blay, Catherine Sebban, Pierre Biron, Thierry O. Philip 797

46. High-Dose Chemotherapy in Patients with Germ Cell Cancer / Craig R. Nichols, Richard Maziarz 807

47. Dose-Intensive Therapy for Breast Cancer / Linda T. Vahdat, Karen H. Antman 821

48. Lung Cancer / Daniel B. Rubinstein, Theirry Guillaume, Ken S. Zaner, Yves Humblet, Michel L. Symann 841

49. High-Dose Chemotherapy and Stem Cell Transplantation for Ovarian Cancer / Patrick J. Stiff 853

50. High-Dose Therapy and Stem Cell Transplantation for Neuroblastoma and Other Pediatric Solid Tumors / Bruce G. Gordon, Peter F. Coccia 871

51. Brain Tumors / Kyriakos P. Papadopoulos, Charles S. Hesdorffer 895

52. Other Solid Tumors / Bruce D. Cheson 909.

Notes:

Includes bibliographical references and index.

ISBN:

0683306545

OCLC:

41606508