Ion channels and disease : channelopathies / Frances M. Ashcroft.

Format:

Book

Author/Creator:

Ashcroft, Frances M.

Language:

English

Subjects (All):

Ion channels.

Genetic disorders--Molecular aspects.

Genetic disorders.

Membrane proteins.

Ion Channels.

Genetic Diseases, Inborn.

Membrane Proteins.

Medical Subjects:

Ion Channels.

Genetic Diseases, Inborn.

Membrane Proteins.

Physical Description:

xxi, 481 pages, 5 unnumbered pages of color leaves : illustrations ; 26 cm

Other Title:

Channelopathies

Place of Publication:

San Diego : Academic Press, [2000]

Summary:

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.

Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.

This book is intended for research workers and clinicians, as well as for graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to the frontiers of what is currently known about this most exciting and medically important area of physiology.

Notes:

Includes bibliographical references and index.

ISBN:

0120653109

OCLC:

42686352