Sphingolipid metabolism and cell signaling / edited by Alfred H. Merrill Jr., Yusuf A. Hannun.

Format:

Book

Contributor:

Merrill, Alfred H. (Alfred Harrison), 1951-

Yusuf, A. Hannun.

Series:

Methods in enzymology ; v. 311-312.

Methods in enzymology ; v. 311-312

Language:

English

Subjects (All):

Sphingolipids.

Cellular signal transduction.

Physical Description:

2 volumes : illustrations (some color) ; 24 cm.

Place of Publication:

San Diego, Calif. : Academic Press, [2000]

Summary:

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and p.raised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today -- truly an essential publication for researchers in all fields of life sciences.

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion, Volume 312, will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.

Contents:

Part A. Sphingolipid metabolism

Inhibitors of sphingolipid biosynthesis

Chemical and enzymatic synthesis

Part B. [No special title]

Notes:

Includes bibliographical references and indexes.

ISBN:

0121822125

OCLC:

42997705