Drug resistance in leukemia and lymphoma III / edited by G.J.L. Kaspers, R. Pieters and A.J.P. Veerman.

Format:

Book

Conference/Event

Contributor:

Kaspers, G. J. L., 1963-

Pieters, R.

Conference Name:

International Symposium on Drug Resistance in Leukemia and Lymphoma (3rd : 1998 : Amsterdam, Netherlands)

Series:

Advances in experimental medicine and biology ; v. 457.

Advances in experimental medicine and biology ; v. 457

Language:

English

Subjects (All):

Leukemia--Molecular aspects--Congresses.

Leukemia.

Leukemia--Molecular aspects.

Lymphomas--Molecular aspects--Congresses.

Lymphomas.

Drug resistance in cancer cells--Congresses.

Drug resistance in cancer cells.

Leukemia--drug therapy.

Lymphoma--drug therapy.

Drug Resistance, Neoplasm--physiology.

Medical Subjects:

Leukemia--drug therapy.

Lymphoma--drug therapy.

Drug Resistance, Neoplasm--physiology.

Genre:

Conference papers and proceedings.

Physical Description:

xiv, 638 pages : illustrations ; 26 cm.

Place of Publication:

New York : Plenum Press, [1999]

Contents:

Section I. Drug Resistance Related Proteins and Glutathione

1. MDR1/P-gp Expression as a Prognostic Factor in Acute Leukemias / Jean-Pierre Marie, Ollivier Legrand 1

2. Clinical Significance of P-Glycoprotein (P-gp) Expression in Childhood Acute Lymphoblastic Leukemia: Results of a 6-Year Prospective Study / Catharina Dhooge, Barbara De Moerloose 11

3. Prognostic Value of P-gp Expression and Related Function in Childhood Acute Leukemia / Z. Karakas, L. Agaoglu, S. Erdem, G. Yanikkaya Demirel, M. Arasa, F. Suzergoz, G. Deniz, S. Anak, G. Gedikoglu 21

4. Comparison of P-Glycoprotein Expression and Function with in Vitro Sensitivity to Anthracyclines in AML / Alena W. Elgie, Jean M. Sargent, Christine J. Williamson, Grazyna M. Lewandowicz, Colin G. Taylor 29

5. Quinine Improves Results of Intensive Chemotherapy (IC) in Myelodysplastic Syndromes (MDS) Expressing P-Glycoprotein (PGP): Updated Results of a Randomized Study / E. Wattel, E. Solary, B. Hecquet, D. Caillot, N. Ifrah, A. Brion, N. Milpied, M. Janvier, A. Guerci, H. Rochant, C. Cordonnier, F. Dreyfus, A. Veil, L. Hoang-Ngoc, A. M. Stoppa, N. Gratecos, A. Sadoun, H. Tilly, P. Brice, B. Lioure, B. Desablens, B. Pignon, J. P. Abgrall, M. Leporrier, B. Dupriez, D. Guyotat, P. Lepelley, P. Fenaux 35

6. Treatment of Poor Prognosis AML Patients Using PSC833 (Valspodar) plus Mitoxantrone, Etoposide, and Cytarabine (PSC-MEC) / R. Advani, G. Visani, D. Milligan, H. Saba, M. Tallman, J. M. Rowe, P. H. Wiernik, J. Ramek, K. Dugan, B. Lum, J. Villena, E. Davis, E. Paietta, M. Litchman, A. Covelli, B. Sikic, P. Greenberg 47

7. Assessment of P-Glycoprotein Expression by Immunocytochemistry and Flow Cytometry Using Two Different Monoclonal Antibodies Coupled with Functional Efflux Analysis in 34 Patients with Acute Myeloid Leukemia / S. Poulain, P. Lepelley, N. Cambier, A. Cosson, P. Fenaux, E. Wattel 57

8. Preliminary Immunocytochemical Studies of MDR-1 and MDR-3 Pgp Expression in B-Cell Leukaemias / Annemarie Larkin, Elizabeth Moran, Denis Alexander, Martin Clynes 65

9. A Mutation in the Promoter of the Multidrug Resistance Gene (MDR1) in Human Hematological Malignancies May Contribute to the Pathogenesis of Resistant Disease / Deborah Rund, Idit Azar, Olga Shperling 71

10. Reproducible Flow Cytometric Methodology for Measuring Multidrug Resistance in Leukaemic Blasts / M. Pallis, J. Turzanski, S. Langabeer, N. H. Russell 77

11. Natural Fluorescence Imaging of Leukemic Cells for Studying Uptake and Retention of Anthracyclines / M. Monici, F. Fusi, P. Mazzinghi, A. Degli Innocenti o Nocentini, I. Landini, I. Banchelli, B. Bartolozzi, V. Santini, P. A. Bernabei 89

12. Artificial Neural Networks as Versatile Tools for Prediction of MDR-Modulatory Activity / C. Tmej, P. Chiba, K.-J. Schaper, G. Ecker, W. Fleischhacker 95

13. Discordance of P-Glycoprotein Expression and Function in Acute Leukemia / Barbara De Moerloose, Catharina Dhooge, Jan Philippe 107

14. Multidrug Resistance Related Proteins in Primary Cutaneous Lymphomas Christian W. van Haselen, Marcel J. Flens, Rik J. Scheper / Paul van der Valk, George L. Scheffer, Johan Toonstra, Willem A. van Vloten 119

15. The Lung Resistance Protein (LRP) Predicts Poor Outcome in Acute Myeloid Leukemia / Robert Pirker, Gudrun Pohl, Thomas Stranzl, Ralf W. Suchomel, Rik J. Scheper, Ulrich Jager, Klaus Geissler, Klaus Lechner, Martin Filipits 133

16. MRP Expression in Acute Myeloid Leukemia: An Update / Martin Filipits, Thomas Stranzl, Gudrun Pohl, Ralf W. Suchomel, Sabine Zochbauer, Raoul Brunner, Klaus Lechner, Robert Pirker 141

17. Evidence for Functional Discrimination between Leukemic Cells Overexpressing Multidrug-Resistance Associated Protein and P-Glycoprotein / Zineb Benderra, Hamid Morjani, Aurelie Trussardi, Michel Manfait 151

18. Both Pgp and MRP1 Activities Using Calcein-AM Contribute to Drug Resistance in AML / Ollivier Legrand, Ghislaine Simonin, Jean-Yves Perrot, Robert Zittoun, Jean-Pierre Marie 161

19. Absolute Levels of MDR-1, MRP, and BCL-2 mRNA and Tumor Remission in Acute Leukemia / T. Kohler, S. Leiblein, S. Borchert, J. Eller, A.-K. Rost, D. La[sz ligature]ner, R. Krahl, W. Helbig, O. Wagner, H. Remke 177

20. Multidrug Resistance Protein MRP1, Glutathione, and Related Enzymes: Their Importance in Acute Myeloid Leukemia / Dorina M. van der Kolk, Edo Vellenga, Michael Muller, Elisabeth G. E. de Vries 187

21. Glutathione and the Regulation of Cell Death / A. G. Hall 199

22. Evidence for the Involvement of the Glutathione Pathway in Drug Resistance in AML / J. M. Sargent, C. Williamson, A. G. Hall, A. W. Elgie, C. G. Taylor 205

23. Glutathione in Childhood Acute Leukaemias / P. Kearns, R. Pieters, M. M. A. Rottier, A. J. P. Veerman, K. Schmiegalow, A. D. J. Pearson, A. G. Hall 211

Section II. Apoptosis and Cell Death Regulations

24. Apoptosis: Molecules and Mechanisms / Marina Konopleva, Shourong Zhao, Zhong Xie, Harry Segall, Anas Younes, David F. Claxton, Zeev Estrov, Steven M. Kornblau, Michael Andreeff 217

25. Activation of Apoptosis Pathways by Anticancer Drugs / Klaus-Michael Debatin 237

26. BCL-2 Stimulates Apoptin-Induced Apoptosis / Astrid A. A. M. Danen-Van Oorschot, Alex J. van der Eb, Mathieu H. M. Noteborn 245

27. CD95 (Fas/Apo-1) Antigen Is a New Prognostic Marker of Blast Cells of Acute Lymphoblastic Leukaemia Patients / A. Yu. Baryshnikov, E. R. Polosukhina, N. N. Tupitsin, N. V. Gavrikova, L. Yu. Andreeva, T. N. Zabotina, S. A. Mayakova, V. I. Kurmashov, A. B. Syrkin, Z. G. Kadagidze, D. Yu. Blochin, Yu. V. Shishkin 251

28. Inhibition of Fas/Fas-Ligand Does Not Block Chemotherapy-Induced Apoptosis in Drug Sensitive and Resistant Cells / Deborah S. Richardson, Paul D. Allen, Stephen M. Kelsey, Adrian C. Newland 259

29. Effects of PARP Inhibition on Drug and FAS-Induced Apoptosis in Leukaemic Cells / Deborah S. Richardson, Paul D. Allen, Stephen M. Kelsey, Adrian C. Newland 267

30. Apoptotic Fraction in Childhood ALL Assessed by DNA in Situ Labelling Is Ploidy Independent / Allen F. Pyesmany, Lynne M. Ball, Margaret Yhap, M. Henry, Krista Laybolt, D. Christie Riddell, Dick van Velzen 281

31. PCNA Bearing Structures Are Retained in Apoptotic Phase of Childhood ALL Cell Cycle / Lynne M. Ball, Christopher L. Lannon, Margaret Yhap, Allen F. Pyesmany, M. Henry, Krista Laybolt, D. Christie Riddell, Dick van Velzen 289

32. Apoptosis Corrected Proliferation Fraction in Childhood ALL Is Related to Karyotype / Lynne M. Ball, Allen F. Pyesmany, Margaret Yhap, Christopher L. Lannon, M. Henry, Krista Laybolt, D. Christie Riddell, Dick van Velzen 297

33. Proliferation and Apoptosis Does Not Affect Presenting White Cell Count in Childhood ALL / Allen F. Pyesmany, Lynne M. Ball, Margaret Yhap, M. Henry, Krista Laybolt, D. Christie Riddell, Dick van Velzen 305

34. Apoptosis by Anthracyclines at Therapeutic Concentrations in MDR1+ Human Leukemic Cells / Barbara Chiodini, Renato Bassan, Tiziano Barbui 313

35. BCL-2 Expression in Childhood Leukemia versus Spontaneous Apoptosis, Drug Induced Apoptosis and in Vitro Drug Resistance / E. G. Haarman, G. J. L. Kaspers, R. Pieters, C. H. van Zantwijk, G. J. Broekema, K. Hahlen, A. J. P. Veerman 325

36. Comparison of BCL-2 and Bax Protein Expression with in Vitro Sensitivity to Ara-C and 6TG in AML / S. E. Balkham, J. M. Sargent, A. W. Elgie, C. J. Williamson, C. G. Taylor 335

37. Synthetic Cyclin Dependent Kinase Inhibitors: New Generation of Potent Anti-Cancer Drugs / Marian Hajduch, Libor Havlieek, Jaroslav Vesely, Radko Novotny, Vladimir Mihal, Miroslav Strnad 341

38. Factors Contributing to the Resistance to Apoptosis Induced by Topoisomerase I Inhibitors in Vincristine Resistant Cells / Valerie Palissot, Aurelie Trussardi, Marie-Claude Gorisse, Jean Dufer 355

39. Two Distinct Modes of Oncoprotein Expression during Apoptosis Resistance in Vincristine and Daunorubicin Multidrug-Resistant HL60 Cells / Rajae Belhoussine, Hamid Morjani, Reynald Gillet, Valerie Palissot, Michel Manfait 365

Section III. Risk Factors and Cell Culture Assays

40. Genetic Abnormalities and Drug Resistance in Acute Lymphoblastic Leukemia / Ching-Hon Pui, William E.

Evans 383

41. Resistance Testing and Mechanisms of Resistance in Childhood Leukemia: Studies from Amsterdam / R. Pieters, G. J. L. Kaspers, N. L. Ramakers-van Woerden, M. L. den Boer, M. G. Rots, Ch. M. Zwaan, E. G. Haarman, A. J. P. Veerman 391

42. Pharmacokinetics of Anticancer Drugs in Vitro / Alexandra Wagner, Georg Hempel, Gumbinger H. G., Heribert Jurgens, Joachim Boos 397

43. Down Syndrome and Acute Myeloid Leukemia: Lessons Learned from Experience with High-Dose Ara-C Containing Regimens / Yaddanapudi Ravindranath, Jeffrey W. Taub 409

44. Cellular Drug Resistance in Childhood Acute Myeloid Leukemia: A Mini-Review with Emphasis on Cell Culture Assays / G. J. L. Kaspers, Ch. M. Zwaan, R. Pieters, A. J. P. Veerman 415

45. Is in Vitro Sensitivity of Blast Cells Correlated to Therapeutic Effect in Childhood Acute Lymphoblastic Leukemia? / Britt-Marie Frost, Rolf Larsson, Peter Nygren, Gudmar Lonnerholm 423

46. In Vitro Cytotoxic Drug Activity and in Vivo Pharmacokinetics in Childhood Acute Myeloid Leukemia / Gudmar Lonnerholm, Britt-Marie Frost, Rolf Larsson, E. Liliemark, Peter Nygren, Curt Peterson 429

47. Prognosis in Adult AML Is Precisely Predicted by the Disc-Assay Using the Chemosensitivity-Index C[subscript 1] / Peter Staib, Bernd Lathan, Timo Schinkothe, Sabine Wiedenmann, Bernhard Pantke, Thomas Dimski, Dimitris Voliotis, Volker Diehl 437

48. Drug Resistance Testing of Acute Myeloid Leukemia in Adults Using the MTT Assay / N. Stute, T. Kohler, L. Lehmann, W. Wetzstein, G. Ehninger 445

49. MTT Assay for Drug Resistance in Childhood Acute Leukemia and Effect of Cyclosporin and Interferon: A Preliminary Report / Zeynep Karakas, Leyla Agaoglu, Serap Erdem, Sema Anak, Aysegul Hacibektasoglu, Gunduz Gedikoglu 453

50. Differential Antileukemic Activity of Prednisolone and Dexamethasone in Freshly Isolated Leukemic Cells / Vladimir Mihal, Marian Hajduch, Vera Noskova, Gabriela Feketova, Kassmine Jess, Libuse Gojova, Ivo Kasparek, Jan Stary, Bohumir Blazek, Dagmar Pospisilova, Zbynik Novak 459

51. Activity of Vinorelbine on B-Chronic Lymphocytic Leukemia Cells in Vitro / P.A. Bernabei, I. Landini, B. Bartolozzi, I. Banchelli, A. Degli Innocenti o Nocentini, V. Santini 473

52. Studies of Some Mechanisms of Drug Resistance in Chronic Myeloid Leukemia (CML) / Anna G. Turkina, Natalia P. Logacheva, Tatjana P. Stromskaya, Tatjana N. Zabotina, Sergei V. Kuznetzov, Kuralay K. Sachibzadaeva, Akshin Tagiev, Vacheslav S. Juravlev, Nina D. Khoroshko, Anatoly Y. Baryshnikov, Alla A. Stavrovskaya 477

53. Clinical Sensitivity to Anthracyclines in Ph/BCR+ Acute Lymphoblastic Leukemia / Renato Bassan, Ama Z. S. Rohatiner, Alessandro Rambaldi, Teresa Lerede, Eros Di Bona, Maxine Carter, Giuseppe Rossi, Enrico Pogliani, Giorgio Lambertenghi-Deliliers|cPiero Fabris, Adolfo Porcellini, T. Andrew Lister, Tiziano Barbui 489

54. Differential Kinetics of Drug Resistance in Human Leukaemic Cells Measured by SCGE/CLSM / Lynne M. Ball, Christopher L. Lannon, G. Ross Langley, Allen F. Pyesmany, Margaret Yhap, Dick van Velzen 501

55. Demonstration of Differences in Drug Resistance by Direct Testing of DNA Excision Repair Activity following Standard and Liposomal Daunorubicin Exposure in Normal Paediatric Marrow Using High Resolution CLSM / Christopher L. Lannon, Lynne M. Ball, Allen F. Pyesmany, Margaret Yhap, G. Ross Langley, Dick van Velzen 509

56. Microsatellite Instability Assessment in Prediction of Drug Resistance in Childhood Burkitt's and Large Cell Diffuse Malignant Non-Hodgkin Lymphoma (MNHL) / Margaret Yhap, Allen F. Pyesmany, Lynne M. Ball, D. Christie Riddle, Jiang Mu, Dick van Velzen 517

57. High Resolution Confocal Laser Scanning Microscopy Analysis of DNA Excision Repair Capability in Small Volume Marrow Samples Exposed to DNA Directed Treatment Moieties / Christopher L. Lannon, Lynne M. Ball, Allen F. Pyesmany, Margaret Yhap, Ross Langley, Dick van Velzen 527

Section IV. Antifolates

58. Defining the Optimal Dosage of Methotrexate for Childhood Acute Lymphoblastic Leukemia: New Insights from the Lab and Clinic / William E. Evans, Ching-Hon Pui, Mary V. Relling 537

59. Mechanisms of Methotrexate Resistance in Acute Leukemia: Decreased Transport and Polyglutamylation / Richard Gorlick, Peter Cole, Debabrata Banerjee, Giuseppe Longo, Wei Wei Li, Daniel Hochhauser, Joseph R. Bertino 543

60. Lack of Cross-Resistance between Prednisolone and Methotrexate in Childhood Acute Lymphoblastic Leukemia? A Preliminary Analysis / I. R. H. J. Hegge, G. J. L. Kaspers, M. G. Rots, G. Jansen, R. Pieters, A. J. P. Veerman 551

Section V. Nucleoside Analogues and Growth Factors

61. New Developments in the Treatment of Acute Myeloid Leukemia / Marielle Smeets, Theo de Witte, Netty van der Lely, Reinier Raymakers, Petra Muus 557

62. Aphidicolin Markedly Increases the in Vitro Sensitivity to Ara-C of Blast Cells from Patients with AML / J. M. Sargent, A. W. Elgie, C. J. Williamson, C. G. Taylor 567

63. Common Resistance Mechanisms to Nucleoside Analogues in Variants of the Human Erythroleukemic Line K562 / Charles Dumontet, Evelyne Callet Bauchu, Krystyna Fabianowska, Michel Lepoivre, Dorota Wyczechowska, Frederique Bodin, Marie Odile Rolland 571

64. Expression of DNA Mismatch Repair Proteins in Acute Lymphoblastic Leukaemia and Normal Bone Marrow / E. C. Matheson, A. G. Hall 579

65. Effects of CSFS and Their Combinations with Chemotherapeutic Agents (Ch) on Leukemic Blasts (LB) in Children (MTT-Assay) / E. Litvinova, K. Gurova, K. Chimishkian, G. Mentkevich 585

Section VI. Glucocorticoids

66. Glucocorticosteroid Therapy in Childhood Acute Lymphoblastic Leukemia / Paul S. Gaynon, Aaron L. Carrel 593

67. Glucocorticoid Induced Apoptosis in Leukemia / Lou A. Smets, Gajja Salomons, Joop van den Berg 607

68. Glucocorticoid Resistance and the AP-1 Transcription Factor in Leukemia / S. Bailey, A. G. Hall, A. D. J. P. Pearson, M. M. Reid, C. P. F. Redfern 615

Section VII. Asparaginase

69. The Three Asparaginases: Comparative Pharmacology and Optimal Use in Childhood Leukemia / Barbara L. Asselin 621.

Notes:

"Proceedings of the Third International Symposium on Drug Resistancein Leukemia and Lymphoma, held March 4-7, in Amsterdam, the Netherlands"--T.p. verso.

Includes bibliographical references and index.

ISBN:

0306460556

OCLC:

40075911