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Drugs in anaesthetic and intensive care practice / M.D. Vickers ... [and others].
Holman Biotech Commons RD82 .D78 1999
Available
- Format:
- Book
- Language:
- English
- Subjects (All):
- Anesthetics.
- Anesthesia adjuvants.
- Critical care medicine.
- Adjuvants, Anesthesia.
- Critical Care.
- Medical Subjects:
- Anesthetics.
- Adjuvants, Anesthesia.
- Critical Care.
- Physical Description:
- xx, 526 pages : illustrations ; 24 cm
- Edition:
- Eighth edition.
- Other Title:
- Drugs in anesthetic and intensive care practice
- Place of Publication:
- Oxford ; Woburn, MA : Butterworth-Heinemann, 1999.
- Summary:
- Specialists from the Universities of London and Cardiff revise what through the 1991 seventh edition was Drugs in Anaesthetic Practice, and incorporate drugs used in intensive care as well. They group the drugs according to therapeutic strategy, system or receptor group on which they act, or common chemical features and name them by the recommended International Nonproprietary Names as designated by the Medicines Control Agency. They also discuss dosage, effects, and precautions of each drug. They have rearranged the chapters to separate more explicitly the uses as a learning tool and a reference for specific problems, putting the pharmacology and other basic science at the beginning and the monographs of individual drugs in the back. In addition to drugs used for anesthesia, they include drugs that patients are sometimes given before surgery that may interact with anesthetic drugs.
- Contents:
- 1 General pharmacology 1
- Mechanisms of action of drugs 2
- Concept of a receptor 4
- Characterization and classification of receptors 5
- Receptor types and subtypes 12
- G-Protein-coupled receptors 14
- Drug interactions 16
- Transfer of drugs across membranes 20
- Physical properties affecting transfer 21
- Transfer across special membranes 23
- Routes of drug administration 23
- Factors affecting drug dosage 27
- Timing of administration 28
- Binding of drugs 29
- Distribution of drugs in the body 30
- Drug metabolism 30
- Drug excretion 33
- Factors determining biophase concentration 34
- Compartment models 36
- Drug elimination 38
- Pharmacokinetic compartment models 39
- Pharmacokinetics of inhalation anaesthetics 43
- Bioavailability 44
- First-pass effect 44
- Automated drug delivery systems 46
- Idiosyncrasy 48
- Allergic reactions (anaphylactic reactions) 48
- Blood dyscrasias 50
- Pharmacogentics 50
- Chemotherapeutic index 52
- Approved names 52
- Clinical trials 53
- Legal aspects of medicines 56
- 2 Perioperative therapy 61
- Anxiety 61
- Unwanted autonomic responses to anaesthesia 62
- Induction movements 62
- Regurgitation, vomiting and pulmonary aspiration 62
- Premedication in children 66
- Metoclopramide 67
- Omeprazole 67
- Ondanstron 68
- 3 Central nervous system depressants 70
- Narcotics, hypnotics, anxiolytic sedatives, neuroleptics and general anaesthetics 70
- Anxiolytic sedatives (minor tranquillizers) 71
- Benzodiazepines 73
- Other anxiolytic sedatives: chemical variants 79
- Neuroleptics, major tranquillizers, anti-psychotics 80
- Intravenous induction agents 85
- Steroids 87
- Other sedatives and hypnotics 88
- Forced diuresis in the treatment of drug overdosage 91
- Anticonvulsants 92
- Drug treatment of epilepsy 93
- Alcohol 96
- Alimemazine (trimpeprazine) 97
- Clomethiazole 97
- Diazepam 98
- Droperidol 100
- Etomidate 101
- Flumazenil 102
- Fluphenazine 103
- Haloperidol 104
- Ketamine 104
- Lorazepam 107
- Methohexital 108
- Midazolam 108
- Propofol 111
- Thiopental 115
- 4 General anaesthetics 120
- Stages of anaesthesia 120
- Surgical anaesthesia 121
- Mode of action of anaesthetics 121
- Uptake and distribution of inhalational agents 122
- Metabolism of volatile anaesthetics 126
- Evaluation of anaesthetic potency 127
- Pharmacology 128
- Halogenated hydrocarbon anaesthetics 132
- Anaesthetic gases 132
- Desflurane 133
- Enflurane 134
- Ether 135
- Halothane 138
- Isoflurane 142
- Nitrous oxide 144
- Sevoflurane 147
- Xenon 149
- Agents mainly of historical interest 149
- Chloroform 149
- Cyclopropane 150
- Ethyl chloride 150
- Fluroxene 150
- Methoxyflurane 150
- Trichloroethylene 150
- Vinyl ether 151
- 5 Systemic analgesics 152
- Pain 152
- Analgesics 154
- Peripherally-acting analgesics 163
- Treatment of migraine 169
- Acetylsalicylic acid 171
- Alfentanil 175
- Buprenorphine 176
- Codeine 177
- Diamorphine 178
- Diclofenac 179
- Fentanyl 180
- Ibuprofen 182
- Indometacin 183
- Morphine salts 184
- Naloxone 190
- Nefopam hydrochloride 192
- Paracetamol 192
- Pentazocine 194
- Pethidine 195
- Piroxicam 198
- Remifentanil 199
- Tramadol 201
- 6 Local anaesthetics 203
- Mode of action 203
- Chemistry 204
- Classification 205
- Other pharmacological actions 207
- Toxic effects 209
- Benzocaine 210
- Bupivacaine 210
- Cocaine 212
- Lidocaine 213
- Prilocaine 215
- Ropivacaine 216
- Tetracaine 217
- Other local anaesthetics 219
- 7 Drugs affecting mood 220
- Antidepressants 220
- Amoxapine 226
- Lithium salts 226
- Mianserin 226
- Rolipram 226
- Antidepressent agents and anaesthesia 227
- Psychomotor stimulants 228
- Psychotomimetics (hallucinogens) 230
- Dopamine as a neurotransmitter in the central nervous system 231
- Other CNS stimulants: analeptics 232
- Amfetamine and dexamfetamine 233
- Amitriptyline 234
- Dosulepin 236
- Doxapram 237
- Fluoxetine 238
- Imipramine 239
- Levodopa 240
- Lithium 242
- Methylamfetamine 243
- Moclobemide 244
- 8 Histamine, antihistamines; drugs affecting bronchial calibre 246
- Histamine 246
- Antihistamines 250
- Bronchoconstrictors 254
- Bronchodilators 255
- Mucolytic agents 256
- Drugs for hay fever 256
- Chlorpheniramine 257
- Cimetidine 257
- Cromoglicate 259
- Cyclizine 259
- Ipratropium 261
- Ranitidine 261
- Salbutamol 263
- Theophylline and aminophylline 264
- 9 Neuromuscular blocking agents 266
- Physiology of neuromuscular transmission 266
- Neuromuscular block 267
- Pharmacokinetics of relaxants 272
- Clinical use of relaxants 274
- Abnormal reactions to relaxants 276
- Muscle rigidity and spasm 278
- Alcuronium 279
- Atracurium 279
- Cisatracurium 281
- Dantrolene 282
- Gallamine 283
- Mivacurium 284
- Pancuronium 286
- Rocuronium 287
- Suxamethonium salts 288
- Tubocurarine 291
- Vecuronium 293
- 10 Parasympathomimetic and cholinergic agents; anticholinesterases 296
- Drug action 296
- Anticholinesterases 300
- Myasthenia gravis 302
- Edrophonium 303
- Neostigmine 304
- Physostigmine 306
- Pyridostigmine 307
- 11 Parasympathetic antagonists and anticholinergic agents 309
- Synthetic atropine-like compounds 310
- Belladonna alkaloids 310
- Anti-Parkinsonian drugs 311
- Mydriatics 311
- Atropine 312
- Glycopyrrolate 314
- Hyoscine 315
- Other synthetic anticholinergics 316
- 12 Drugs used for their effects on vascular tone and cardiac contractility 317
- Cardiovascular control mechanisms 317
- The myocardium 320
- Pressor agents and vasoconstrictors 322
- Inotropic agents 325
- Hypotensive agents and vasodilators 330
- Ganglion blocking agents 332
- Agents inhibiting norepinephrine release 333
- Adrenoceptor blocking agents 333
- Inhibitors of angiotensin conversion 335
- Direct-acting vasodilators 336
- Nitric oxide donors 337
- Calcium channel blockers 338
- Phosphodiesterase inhibitors 341
- ATP-ase-dependent potassium channel openers 341
- Adenosine uptake inhibitors 342
- Vasodilators with an unknown mechanism 342
- Drugs affecting coronary blood vessels 342
- Captopril 349
- Clonidine 350
- Dobutamine 352
- Dopamine 353
- Dopexamine 354
- Ephedrine 355
- Epinephrine 355
- Glyceryl trinitrate 356
- Guanethidine 357
- Hydralazine 359
- Isoprenaline salts 359
- Metaraminol 361
- Methoxamine 362
- Methyldopa 363
- Milrinone 364
- Nifedipine 365
- Nimodipine 366
- Nitric oxide 367
- Nitroprusside 367
- Norepinephrine 369
- Phenoxybenzamine 371
- Phentolamine 372
- Phenylephrine 373
- Prazosin 374
- Sildenafil 375
- Trimetaphan 376
- Verapamil 377
- 13 Drugs used for their effects on cardiac rhythm and rate 379
- The cardiac electrical cycle 379
- Cardiac arrhythmias 383
- Anti-arrhythmic agents 383
- Digitalis glycosides 390
- Chronotropic agents 391
- Adenosine 392
- Amiodarone 394
- Atenolol 395
- Digoxin 396
- Disopyramide 398
- Esmolol 399
- Metoprolol 400
- Propranolol 401
- Quinidine 403
- Sotalol 404
- 14 Diuretics 405
- Structure of the nephron 405
- The glomerular filtrate 406
- Modification of the glomerular filtrate 406
- Action of diuretics 407
- Acetazolamide 409
- Furosemide 409
- Mannitol 411
- Spironolactone 412
- Thiazides 413
- Triamterene 414
- 15 Drugs acting on the uterus 416
- Uterine muscle 416
- Uterine stimultants 416
- Tocolytic agents 416
- Ergometrine 418
- Oxytocin 419
- Prostaglandins 420
- 16 Chemical transmitters and enzymes 423
- Chemical transmitters 423
- Autacoids 423
- Prostaglandins 423
- Slow-reacting substance 427
- 5-Hydroxytryptamine 427
- Angiotensin 429
- Plasma kinins 430
- Substance P 430
- Enzymes 431
- Amine oxidases 431
- Carbonic anhydrase 432
- Cholinesterases 433
- Hyaluronidase 434
- Proteinases 435
- 17 Hormones 436
- Effects of anaesthesia 436
- Pituitary gland (hypophysis) and hypothalamus 437
- Adrenal cortex 437
- Adrenal medulla 442
- Thyroid 442
- Antithyroid drugs 442
- Pancreas 443
- Oral hypoglycaemic drugs 450
- Carbimazole 445
- Chlorpropamide 446
- Dexamethasone 446
- Glibendamide 447
- Glucagon 448
- Hydrocortisone 448
- Insulin 449
- Metformin 450
- Octreotide 451
- Prednisolone 451
- Somatotropin 452
- Thyroid hormones 453
- Tolbutamide 453
- Vasopressin 454
- 18 Anticoagulants, antithrombotic, thrombolytic and haemostatic agents 456
- The normal clotting process 456
- Control mechanisms 458
- Sites of action of anticoagulants 458
- Fibrinolysis 459
- Oral anticogulants 461
- Anistreplase 463
- Dextrans 464
- Epoprostenol 465
- Ethamsylate 466
- Heparin 467
- Protamine 469
- Tranexamic acid 470
- Warfarin 470
- 19 Antibiotics and other antimicrobial agents 473
- History 473
- General approach to the use of antibiotics 473
- Mode of action of antibiotics 475
- Mechanisms of antibiotic resistance 477
- Hypersensitivity 478
- Antimicrobial agents 478
- Sulphonamides 478
- [beta]-Lactam antibiotics 479
- Penicillins 479
- Benzylpenicillin 480
- Anti-staphylococcal penicillins 480
- Pencillins active against Gram-negative bacilli 481
- Ampicillin and amoxycillin 481
- Other pencillins active against Gram-negative bacilli 481
- Cephalosporins 481
- Imipenem 483
- Aztreonam 483
- Aminoglycosides 484
- Gentamicin 485
- Macrolides 485
- Erythromycin 485
- Fusidic acid 486
- Tetracyclines 486
- Chloramphenicol 486
- Quinolones 486
- Ciprofloxacin 486
- Glycopeptides 487
- Vancomycin 487
- Teicoplanin 487
- Antimycobacterial agents 487
- Antituberculous agents 487
- Isoniazid 488
- Rifampicin 488
- Ethambutol 489
- Pyrazinamide 489
- @p-Aminosalicylic acid 489
- Cycloserine 489
- Antileprotic agents 490
- Antiprotozal agents 490
- Metronidazole 491
- Antiviral agents 492
- Interferons 492
- Antiviral drugs 492
- Idoxuridine 492
- Amantadine 493
- Cytosine arabinoside 493
- Adenine arabinoside 493
- Acyclovir 493
- Ganciclovir 494
- Zidovudine 494
- Ribavirin 494
- Antifungal agents 495
- The polyenes 495
- Nystatin 495
- Amphotericin B 495
- Fluocytosine 496
- Imidazoles 497
- Clotrimazole 497
- Miconazole 497
- Ketoconazole 497
- Triazoles 498
- Itraconazole 498
- Fluconazole 498
- Griseofulvin 498
- Antimicrobial aerosols 499
- 20 Plasma substitutes 500
- Oxygen-carrying solutions 501
- Dextran 505
- Gelatins 506
- Human albumin 506
- Starch 508
- Appendix Changes in the names of drugs 509.
- Notes:
- Rev. ed. of: Drugs in anaesthetic practice. 7th ed. / M.D. Vickers, M. Morgan, P.S.J. Spencer. 1991.
- Includes bibliographical references and index.
- ISBN:
- 0750637277
- OCLC:
- 40939900
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