Cell and molecular biology of pancreatic carcinoma : recent developments in research and experimental therapy / edited by J.-Matthias Löhr ... [and others].

Format:

Book

Contributor:

Löhr, J.-Matthias.

New York Academy of Sciences.

Series:

Annals of the New York Academy of Sciences ; v. 880.

Annals of the New York Academy of Sciences ; v. 880

Language:

English

Subjects (All):

Pancreas--Cancer--Congresses.

Pancreas.

Pancreas--Cancer.

Pancreatic Neoplasms--genetics.

Cell Transformation, Neoplastic--genetics.

Pancreatic Neoplasms--pathology.

Pancreatic Neoplasms--therapy.

Medical Subjects:

Pancreatic Neoplasms--genetics.

Cell Transformation, Neoplastic--genetics.

Pancreatic Neoplasms--pathology.

Pancreatic Neoplasms--therapy.

Genre:

Conference papers and proceedings.

Physical Description:

xii, 380 pages : illustrations ; 24 cm.

Place of Publication:

New York, N.Y. : New York Academy of Sciences, 1999.

Contents:

Part I. From the Precursor Cell to Carcinoma

Gene Expression in Pancreatic Adenocarcinoma / Marsha L. Frazier 1

Carbonic Anhydrase in Human Pancreas: Hypotheses for the Pathophysiological Roles of CA Isozymes / Isao Nishimori, Kiyomi Fujikawa-Adachi, Saburo Onishi, Michael A. Hollingsworth 5

The Duct Cell in Cystic Fibrosis / Ann Harris 17

Tumor Suppressor Gene Smad4/DPC4, Its Downstream Target Genes, and Regulation of Cell Cycle / Paul J. Chiao, Kelly K. Hunt, Ana M. Grau, Aram Abramian, Jason Fleming, Wei Zhang, Tara Breslin, James L. Abbruzzese, Douglas B. Evans 31

Proteins Expressed by Pancreatic Duct Cells and Their Relatives / Michael A. Hollingsworth 38

Immortalized Pancreatic Duct Cells in Vitro and in Vivo / R. Jesnowski, P. Muller, W. Schareck, S. Liebe, M. Lohr 50

Hyperplastic and Metaplastic Changes in Pancreatic Ducts: Nomenclature and Preneoplastic Potential / Gunter Kloppel, Daniel S. Longnecker 66

Molecular Pathology of Invasive Carcinoma / Daniel S. Longnecker 74

Hollow-Spheres: A New Model for Analyses of Differentiation of Pancreatic Duct Epithelial Cells / Lasse Lehnert, Hartwig Trost, Wolff Schmiegel, Christian Roder, Holger Kalthoff 83

Part II. Cell and Molecular Biology

Sp1 and Its Likes: Biochemical and Functional Predictions for a Growing Family of Zinc Finger Transcription Factors / Tiffany Cook, Brian Gebelein, Raul Urrutia 94

Orthotopic Models of Human Pancreatic Cancer / Gabriel Capella, Lourdes Farre, Alberto Villanueva, German Reyes, Carme Garcia, Gemma Tarafa, Felix Lluis 103

Growth Factors and Cytokines in Pancreatic Carcinogenesis / Helmut Friess, Xiao-Zhong Guo, Bi-Cheng Nan, Org Kleeff, Markus W. Buchler 110

Strategies for the Detection of Disease Genes in Pancreatic Cancer / C. Wallrapp, F. Muller-Pillasch, A. Micha, C. Wenger, M. Geng, S. Solinas-Toldo, P. Lichter, M. Frohme, J.D. Hoheisel, G. Adler, T.M. Gress 122

@p22/PRG1: A Novel Early Response Gene in Pancreatic Cancer Cells Regulated by p53 and NF[kappa]B / Wolfgang E. Schmidt, Alexander Arlt, Ania Trauzold, Heiner Schafer 147

Protein Tyrosine Dephosphorylation and the Maintenance of Cell Adhesions in the Pancreas / J. Schnekenburger, J. Mayerle, P. Simon, W. Domschke, M.M. Lerch 157

Differentially Expressed Genes in Normal and Tumor Pancreatic Tissue / C. Backhaus, S. Schneuer, R. Jesnowski, S. Liebe, M. Lohr 166

Typing of Leukocytes in Pancreatic Tissue Surrounding Human Pancreatic Carcinoma / Jorg Emmrich, Gisela Sparmann, Ulrich Hopt, Matthias Lohr, Stefan Liebe 171

Apoptotic Molecules in Pancreatic Carcinoma Cell Lines / B. Ringel, S.M. Ibrahim, H. Kohler, J. Ringel, D. Koczan, S. Liebe, M. Lohr, H.-J. Thiesen 175

Part III. From Carcinogens to Carcinogenesis

Genomic Anomalies in Pancreatic Tumors Other Than Common Adenocarcinoma / Aldo Scarpa, Giuseppe Zamboni 179

Pancreatic Cancer: Development of a Unifying Etiologic concept / Albert B. Lowenfels, Patrick Maisonneuve 191

Part IV. From Fibrosis to Carcinoma

Hereditary Pancreatitis and Pancreatic Carcinoma / David C. Whitcomb, Suzanne Applebaum, Stephen P. Martin 201

Ki-Ras Oncogene Mutations in Chronic Pancreatitis: Which Discriminating Ability for Malignant Potential? / J.L. van Laethem 210

Acinar-Ductal-Carcinoma Sequence in Transforming Growth Factor-[alpha] Transgenic Mice / Roland M. Schmid, Gunther Kloppel, Guido Adler, Martin Wagner 219

The Course of Pancreatic Fibrosis Induced by Dibutyltin Dichloride (DBTC) / J. Merkord, H. Weber, G. Sparmann, L. Jonas, G. Hennighausen 231

CD44, bFGF and Hyaluronan in Human Pancreatic Cancer Cell Lines / Jorg Ringel, Joachim Rychly, Barbara Nebe, Christian Schmidt, Petra Muller, Jens Ringel, Jorg Emmrich, Stefan Liebe, Matthias Lohr 238

Part V. From Experimental to Applied Therapeutic Strategies

Immunological Escape Mechanisms in Pancreatic Carcinoma / Hendrik Ungefroren, Martina Voss, Wolfram V. Bernstorff, Andreas Schmid, Bernd Kremer, Holger Kalthoff 243

The Novel Trk Receptor Tyrosine Kinase Inhibitor CEP-701 (KT-5555) Exhibits Antitumor Efficacy against Human Pancreatic Carcinoma (Panc1) Xenograft Growth and In Vivo Invasiveness / Sheila J. Miknyoczki, Craig A. Dionne, Andres J.P. Klein-Szanto, Bruce A. Ruggeri 252

Single-Chain Antibodies in Pancreatic Cancer / David Colcher, Gabriela Pavlinkova, Guy Beresford, Barbara J.M. Booth, Surinder K. Batra 263

@p53 in Relation to Therapeutic Outcome of Locoregional Chemotherapy in Pancreatic Cancer / Frank Gansauge, Susanne Gansauge, Karl H. Link, Hans G. Beger 281

The Matrix Metalloproteinases and Their Inhibitors in the Treatment of Pancreatic Cancer / Lucie Jones, Paula Ghaneh, Michelle Humphreys, John P. Neoptolemos 288

Exocrine Pancreatic Function following Pancreatectomy / Paula Ghaneh, John P. Neoptolemos 308

Genetic Prodrug Activation Therapy for Pancreatic Cancer / A.S. Rigg, N.R. Lemoine 319

Characterization of a Human Cell Clone Expressing Cytochrome P450 for Safe Use in Human Somatic Cell Therapy / Walter H. Gunzburg, Peter Karle, Renate Renz, Brian Salmons, Matthias Renner 326

Injection of Encapsulated Cells Producing an Ifosfamide-Activating Cytochrome P450 for Targeted Chemotherapy to Pancreatic Tumors / Petra Muller, Ralf Jesnowski, Peter Karle, Regina Renz, Robert Saller, Hartmut Stein, Katrin Puschel, Kerstin von Rombs, Horst Nizze, Stefan Liebe, Thomas Wagner, Walter H. Gunzburg, Brian Salmons, Matthias Lohr 337

Discussion Paper

Ablation of Tumor Cells In Vivo by Direct Injection of HSV-Thymidine Kinase Retroviral Vector and Ganciclovir Therapy / Bradley D. Howard, Holger Kalthoff, Timothy C. Fong 352

Poster Papers

Enhanced Retroviral Transduction Efficiency of Pancreatic Tumor Cell Lines Using Different Envelope Glycoproteins / Bradley D. Howard, Lars Boenicke, Wulf Schneider-Brachert, Holger Kalthoff 366

Construction of Recombinant Retroviruses Expressing Mutated k-ras or Mutated p53 Genes / Lilian Kadaja, Ralf Jesnowski, Toivo Maimets, Stefan Liebe, Matthias Lohr 371

Intraarterial Instillation of Microencapsulated Cells in the Pancreatic Arteries in Pig / Jens C. Kroger, Helga Bergmeister, Anne Hoffmeyer, Manfred Ceijna, Peter Karle, Robert Saller, Ilse Schwendenwein, Kerstin von Rombs, Stefan Liebe, Walter H. Gunzburg, Brian Salmons, Karlheinz Hauenstein, Udo Losert, Matthias Lohr 374.

Notes:

Includes bibliographical references and index.

"This volume contains the papers presented at a conference entitled 'Baltic Pancreas Meeting on Pancreatic Carcinoma from Bench to Bedside'"--p.iii.

ISBN:

1573312193

1573312207

OCLC:

41482507