Endotoxin in health and disease / edited by Helmut Brade ... [and others].

Format:

Book

Contributor:

Brade, Helmut, 1948-

Language:

English

Subjects (All):

Endotoxins.

Medical Subjects:

Endotoxins.

Physical Description:

xviii, 950 pages : illustrations ; 29 cm

Place of Publication:

New York : Marcel Dekker, [1999]

Summary:

This comprehensive collection, written by 140 internationally recognized experts in their field, gathers up-to-date findings and details basic structures, functions, and immunology -- offering a basis for further research into the interactions of hosts and pathogens.

Created to serve as a primary, one-of-a-kind reference, Endotoxin in Health and Disease discusses basic biochemistry and structural and functional relationships of bacterial endotoxin...covers common pathogenic microorganisms as well as uncommon gram-negative bacterial species important to the understanding of gastrointestinal pathology, periodontal disease, and normal physiology...examines the immunology of, and the cellular and humoral response to, bacterial endotoxin...explores the physiology and pathophysiology of endotoxin-induced host responses...describes the effects of endotoxin, specific cell lines, animal models, and humans in normal physiological and pathological states...concentrates on the clinical consequences of endotoxin exposure in humans...addresses the potential clinical utility of modifying endotoxin-induced pathophysiological events in clinical medicine...and more.

Contents:

1 Endotoxin: Historical Perspectives / Ernst T. Rietschel, Otto Westphal 1

2 Lipopolysaccharide and the Permeability of the Bacterial Outer Membrane / Martii Vaara 31

3 Lipopolysaccharide Phase Variation in Haemophilus and Neisseria / Derek W. Hood, E. Richard Moxon 39

4 Antigenic Mimicry in Neisseria Species / Peter C. Giardina, Andrew Preston, Brad Gibson, Michael A. Apicella 55

5 Antibiotic-Induced Endotoxin Release: Important Parameters Dictating Responses / Jesse J. Jackson, Helmut Kropp 67

6 Complement-Mediated Lipopolysaccharide Release / Vernon L. Tesh 77

7 Chemical Structure of Lipid A: Recent Advances in Structural Analysis of Biologically Active Molecules / Ulrich Zahringer, Buko Lindner, Ernst T. Rietschel 93

8 Chemical Structure of the Core Region of Lipopolysaccharides / Otto Holst 115

9 The Chemistry of O-Polysaccharide Chains in Bacterial Lipopolysaccharides / Per-Erik Jansson 155

10 The Chemistry and Biology of Lipooligosaccharides: The Endotoxins of Bacteria of the Respiratory and Genital Mucosae / J. McLeod Griffiss, Herman Schneider 179

11 A Biophysical View on the Function and Activity of Endotoxins / Ulrich Seydel, Andre Wiese, Andra B. Schromm, Klaus Brandenburg 195

12 Lipopolysaccharide Preparations in Aqueous Media: Implications for Solution Versus Suspension / Pasupati Mukerjee, Manfred Kastowsky, Stefan Obst, Kuni Takayama 221

13 Chlamydial Lipopolysaccharide / Helmut Brade 229

14 The Chemical Synthesis of Lipid A / Shoichi Kusumoto, Koichi Fukase, Masato Oikawa 243

15 Chemical Synthesis of Core Structures / Paul Kosma 257

16 Microbial Pathways of Lipid A Biosynthesis / Paul D. Rick, Christian R. H. Raetz 283

17 Biosynthesis and Genetics of Lipopolysaccharide Core / David E. Heinrichs, Miguel A. Valvano, Chris Whitfield 305

18 Genetics and Biosynthesis of Lipopolysaccharide O-Antigens / Wendy J. Keenleyside, Chris Whitfield 331

19 Lipopolysaccharide-Binding Protein / Peter S. Tobias 359

20 Bactericidal/Permeability-Increasing Protein, p15s and Phospholipases A[subscript 2], Endogenous Antibiotics in Host Defense Against Bacterial Infection / Peter Elsbach 369

21 Interactions of Lipopolysaccharides and Lipoproteins / Sander J. H. van Deventer, Dasja Pajkrt 379

22 Effects of Human Hemoglobin on Bacterial Endotoxin In Vitro and In Vivo / Robert J. Roth, Jack Levin 389

23 LPS/Lipid A-Binding Synthetic Peptides / Massimo Porro 403

24 The Interaction of Lipid A and Lipopolysaccharide with Human Serum Albumin / Sunil A. David 413

25 Endothelial Cell Activation by Lipopolysaccharide: Role of Soluble CD14 / Moshe Arditi 423

26 Scavenger Receptors and Lipopolysaccharide / Alexander Shnyra 437

27 The Role of Platelet-Activating Factor in Endotoxin-Related Disease / Taco W. Kuijpers, Tom van der Poll 449

28 CD14, An Innate Immune Receptor for Various Bacterial Cell Wall Components / Artur J. Ulmer, Volker T. El-Samalouti, Ernst T. Rietschel, Hans-Dieter Flad, Roman Dziarski 463

29 The Role of MAP Kinases, Phosphatidylinositol 3-Kinase, and Ceramide in LPS-Induced Signaling in Macrophages / Anthony L. DeFranco, Mary T. Crowley, Alexander J. Finn, Julie Hambleton, Mary Lee MacKichan, Steven L. Weinstein 473

30 Endotoxin Effects on Synthesis of Phosphatidic Acid and Phosphatidic Acid-Derived Diacylglyceride Species / Stuart L. Bursten 483

31 Endotoxic Shock and the Sphingomyelin Pathway / Cecil K. Joseph, Richard N. Kolesnick 497

32 Role of NF-[kappa]B in Macrophage Activation / Tsuneo Suzuki 509

33 Internalization of Lipopolysaccharide by Phagocytes / Richard L. Kitchens, Robert S. Munford 521

34 Multifunctional G Proteins: Implication in Endotoxin Cellular Responses / Lawrence P. Fernando, Michel A. Makhlouf, J. A. Cook 537

35 Immediate Cytokine Responses to Endotoxin: Tumor Necrosis Factor-[alpha] and the Interleukin-1 Family / Charles A. Dinarello 549

36 Platelet-Activating Factor in Sepsis: An Update / Reuven Rabinovici, Fizan Abdullah, Guenther Mathiak, Giora Feuerstein 561

37 Interleukin-10 and Other Suppressive Cytokines / Arnaud Marchant, Michel Goldman, Tom van der Poll 581

38 Nitric Oxide as a Signaling Molecule in the Systemic Inflammatory Response to LPS / Michael J. Parmely 591

39 Studies of the Primate Inflammatory Hemostatic Axis and Its Response to Inflammatory Mediators / Fletcher B. Taylor, Jr. 605

40 Biological Functions of Lipopolysaccharide Antibodies / Matthew Pollack 623

41 Specificity and Neutralizing Properties of Cross-Reactive Anti-Core LPS Monoclonal Antibodies / Franco E. Di Padova, Didier Heumann, Michel Pierre Glauser, Ernst T. Rietschel 633

42 Effects of Lipopolysaccharide on T Cells / Masayasu Nakano, Teruo Kirikae, Toshimasa Nitta 643

43 Immunological Properties of Microbial Outer Membrane Proteins and Their Effects as Modulators of LPS Immunobiology / Kathryn Nixdorff, Dagmar Schilling, Waltraud Ruiner 651

44 Opsonization of Actinobacillus actinomycetemcomitans by LPS-Directed IgG Antibodies in Sera of Juvenile Periodontitis Patients / Mark E. Wilson 667

45 Apoptotic Cell Death in Response to Lipopolysaccharide / Takashi Yokochi 679

46 Nontoxic RsDPLA As a Potent Antagonist of Toxic Lipopolysaccharide / Nilofer Qureshi, Bruce W. Jarvis, Kuni Takayama 687

47 Synthetic Endotoxin Antagonists / Daniel P. Rossignol, William J. Christ, Lynn D. Hawkins, Seiichi Kobayashi, Tsutomu Kawata, Melvyn Lynn, Isao Yamatsu, Yoshito Kishi 699

48 Bacteria-Induced Hypersensitivity to Endotoxin / Marina A. Freudenberg, Thomas Merlin, Andreas Sing, Reinaldo Salomao, Chris Galanos 719

49 Genetic Control of Endotoxin Responsiveness: The Lps Gene Revisited / Stefanie N. Vogel, Nayantara Bhat, Danielle Malo, Salman T. Qureshi 735

50 Endotoxin Tolerance / F. Ulrich Schade, Regina Flach, Sascha Flohe, Matthias Majetschak, Ernst Kreuzfelder, Emilio Dominguez-Fernandez, Jochen Borgermann, Martin Reuter, Udo Obertacke 751

51 Glucocorticoid Control of Endotoxin Responses / Richard Silverstein, Donald C. Johnson, Mari Norimatsu 769

52 Gene Knockout Technology and the Host Response to Endotoxin: Role of CD14 and Other Inflammatory Mediators / Sanna M. Goyert 781

53 Endotoxemia in Primate Models / Heinz Redl, Gunther Schlag, Soheyl Bahrami 795

54 The Value of Animal Models in Endotoxin Research / Steven M. Opal 809

55 Pathophysiological Responses to Endotoxin in Humans / Anthony F. Suffredini, Naomi P. O'Grady 817

56 Endotoxin Detection in Body Fluids: Chemical Versus Bioassay Methodology / Thomas J. Novitsky 831

57 The Relevance of Endotoxin Detection in Sepsis / James Hurley, Jack Levin 841

58 The Role of Gut-Derived Endotoxin in the Pathogenesis of Multiple Organ Dysfunction / Mitchell P. Fink, Michael G. Mythen 855

59 Therapeutic Approaches Targeting Endotoxin-Derived Mediators / Jean-Daniel Baumgartner, Didier Heumann, Michel Pierre Glauser 865

60 Human Responses to Endotoxin: Role of the Genetic Background / Frank Stuber 877

61 Endotoxin, Antibiotics, and Inflammation in Gram-Negative Infections / Jan M. Prins 887

62 Lipopolysaccharide from Oral Bacteria: Role in Innate Host Defense and Chronic Inflammatory Disease / Brian W. Bainbridge, Richard P. Darveau 899

63 Endotoxin and Cancer / Minghuang Zhang, Kevin J. Tracey 915

64 The Future of Endotoxin Research / Helmut Brade, Steven M. Opal, Stefanie N. Vogel, David C. Morrison 927.

Notes:

Includes bibliographical references and index.

ISBN:

0824719441

OCLC:

41299257