Comparative pharmacokinetics : principles, techniques, and applications / Jim E. Riviere.

Format:

Book

Author/Creator:

Riviere, J. Edmond (Jim Edmond)

Language:

English

Subjects (All):

Pharmacokinetics.

Veterinary pharmacology.

Physical Description:

ix, 327 pages : illustrations ; 26 cm

Edition:

First edition.

Place of Publication:

Ames, Iowa : Iowa State University press, 1999.

Summary:

This book presents a unique, highly practical overview of pharmacokinetics. It explains the scientific data and mathematical models of the discipline within the context of biological reality. Comparative Pharmacokinetics uses a complete model of the field -- from facts and constructs to clinical manifestations.

Written for students, researchers, and comparative medicine clinicians, the book thoroughly explains and assesses both mechanistic (compartmental) models and the newer empirical (noncompartmental) models, considering strengths and weaknesses of each. Comparative Pharmacokinetics also explains establishment of appropriate parameters and proper collection and linking of data.

Cross-referenced information provides multiple opportunities for study from a variety of perspectives and ultimately aids decision making. The book concludes with application of techniques to common problems.

Contents:

2. Principles of Drug Movement in the Body 11

3. Absorption 21

4. Distribution 47

5. Renal Elimination 62

6. Hepatic Biotransformation and Biliary Excretion 81

7. Compartmental Models 107

8. Noncompartmental Models 148

9. Nonlinear Models 168

10. Physiological Models 189

11. Dosage Regimens 202

12. Simultaneous Pharmacokinetic-Pharmacodynamic Modeling 215

13. Study Design and Data Analysis 239

14. Population Pharmacokinetic Models and Bayesian Forecasting Applied to Clinical Pharmacokinetics 259

15. Dosage Adjustments in Renal Disease 283

16. Interspecies Extrapolations 296

17. Tissue Residues and Withdrawal Times 308.

Notes:

Includes bibliographical references and index.

ISBN:

0813829313

OCLC:

40200150