Handbook of platelet physiology and pharmacology / edited by Gundu H.R. Rao.

Format:

Book

Contributor:

Rao, Gundu H. R., 1938-

Language:

English

Subjects (All):

Blood platelets--Handbooks, manuals, etc.

Blood platelets.

Blood Platelets.

Medical Subjects:

Blood Platelets.

Genre:

Handbooks and manuals.

Physical Description:

xiv, 553 pages : illustrations ; 25 cm

Place of Publication:

Boston : Kluwer Academic, [1999]

Summary:

Handbook of Platelet Physiology and Pharmacology represents the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology and function. This edited volume provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs. The book presents an excellent overview of biochemistry, receptor biology, signaling mechanisms, calcium homeostasis, molecular pathology, and comparative physiology of platelets, as well as the pharmacology of antiplatelet drugs and clinical trials.

Handbook of Platelet Physiology and Pharmacology will prove a useful reference for hematologists, cell biologists, biochemists, pathologists, and other researchers in the areas of cell biology, pathobiology, atherosclerosis, thrombosis, and biomedical engineering.

Contents:

1. Platelet Physiology & Pharmacology: An overview / Gundu H. R. Rao 1

Receptor Biology

2. Human Platelet Thrombin Receptors and the two Receptor Model for Platelet Activation / G. A. Jamieson, Narendra N. Tandon, Nicholas J Greco 21

3. Platelet Thromboxane Receptors: Biology and Function / Gerhard J. Johnson 38

4. Collagen Receptors: Biology and Functions / Beate Kehrel 80

5. Adenosine Receptors: Biology and Function / Kailash C. Agarwal 102

6. Platelet Activating Factor and Platelets / Shivendra D. Shukla 120

7. Platelet Glycoprotein 1b-V-1X: Biology and Function / K. J. Clemetson 142

8. Fibrinogen Receptors: Biology and Function / Ellinor I. Peerschke 162

Platelet Biochemistry

9. Biochemistry of Platelet Activation / Anita Ryningen, Holm Holmsen 188

10. GTP Binding Proteins in Platelets / Bruce R. Lester 238

11. Platelet Cyclic Nucleotide Phosphodiesterases / Robert W. Colman 251

12. Polyenoic Fatty Acids and Platelet Function / Mahadev Murthy 268

13. Phospholipase A[subscript 2] in Platelets / Mahadev Murthy 293

Experimental Physiology

14. Platelet Biorheology: Adhesive Interactions in Flow / Mony M. Frojmovic 315

15. Platelet Vessel Wall Interactions / Gines Escolar, Maribel Diaz-Ricart 342

16. Platelet-Biomaterial Interactions / Thomas Chandy, Gundu H. R. Rao 362

17. Comparative Physiology of Platelets from Different Species / Douglas J. Weiss 379

Platelet Pathology

18. The Molecular Pathology of Glanzmann's Thrombasthenia / Deborah French 394

19. Congenital Disorders of Platelet Signal Transduction and Secretion / A. Koneti Rao 424

20. Biochemistry of Altered Platelet Reactivity in Hypertension / Huzoor-Akbar 439

Platelet Pharmacology

21. Nitric Oxide-mediated Regulation of Platelet Function / Marek W. Radomski, Anna S. Radomski 458

22. Aspirin, Prostaglandins and Platelet Function: Pharmacology and Thrombosis Prevention / David C. Calverley, Gerald J. Roth 478

23. Current Developments in Anticoagulant and Antithrombotic Agents / Jawed Fareed, Debra Hoppensteadt, Daniel Fareed, Jeanine M. Walenga, Helmut Wolf, Rodger L. Bick 495

24. Randomized Trials of Antiplatelet Therapy / Cathie Sudlow, Colin Baigent 526.

Notes:

Includes bibliographical references and index.

ISBN:

0792385381

OCLC:

41119129