Combination vaccines : development, clinical research, and approval / edited by Ronald W. Ellis.

Format:

Book

Contributor:

Ellis, Ronald W.

Language:

English

Subjects (All):

Combined vaccines.

Vaccines, Combined.

Medical Subjects:

Vaccines, Combined.

Physical Description:

xvi, 279 pages : illustrations ; 24 cm

Place of Publication:

Totowa, N.J. : Humana Press, [1999]

Summary:

A diverse team of leading experts comprehensively review the complex biology of a wide variety of vaccine combinations, as well as the technical, clinical, and regulatory aspects of their development. Topics covered range from the use of immunological correlates of efficacy, rather than efficacy per se, for the evaluation and licensure of vaccine combinations, to preserving a stable immunogenic mixture in appropriate containers according to accepted regulatory standards. Discussed in detail are the trivalent influenza vaccine, the pneumococcal polysaccharide vaccine, the MMR vaccine, the DTP vaccine and its combinations, and the quadrivalent rotavirus vaccine, all of which serve as models for the development of future combinations. Combination Vaccines: Development, Clinical Research, and Approval illuminates all the scientific, clinical, regulatory, and health care issues involved in the research, development, and human use of combination vaccines.

Contents:

1 Pediatric Combination Vaccines / Emmanuel Vidor, Agnes Hoffenbach, Stanley Plotkin 1

2 Combination Vaccines in Adolescents and Adults / Peter A. Gross 35

3 Pharmaceutical Aspects of Combination Vaccines / Dennis M. Katkocin, Chia-Lung Hsieh 51

4 Pediatric Combination Vaccines: Clinical Issues / Peter R. Paradiso, Robert Kohberger 95

5 Immunological Correlates for Efficacy of Combination Vaccines / Ronald W. Ellis 107

6 Influenza Vaccines / Bert E. Johansson 155

7 Vaccines Against Streptococcus pneumoniae / Kenneth R. Brown, Francis M. Ricci 155

8 Rotavirus Vaccines / Paul A. Offit, H. Fred Clark 171

9 Combined Measles, Mumps, and Rubella Vaccines / Maurice R. Hilleman 197

10 Combination Vaccines: Regulatory Considerations for Developers / John R. Vose 213

11 Testing and Licensure of Combination Vaccines for the Prevention of Infectious Diseases / Lydia A. Falk, Karen Midthun, Loris D. McVittie, Karen L. Goldenthal 233

12 Issues for Health Practitioners in the Use of Combination Vaccines / Kathryn M. Edwards, Michael D. Decker 249.

Notes:

Includes bibliographical references and index.

ISBN:

0896037177

OCLC:

40555835