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Genetics of mental disorders : a guide for students, clinicians, and researchers / Stephen V. Faraone, Ming T. Tsuang, Debby W. Tsuang.
Holman Biotech Commons RC455.4.G4 F37 1999
Available
- Format:
- Book
- Author/Creator:
- Faraone, Stephen V.
- Language:
- English
- Subjects (All):
- Mental illness--Genetic aspects.
- Mental illness.
- Medical genetics--Psychological aspects.
- Medical genetics.
- Genetic Predisposition to Disease--genetics.
- Genetic Diseases, Inborn--genetics.
- Mental Disorders--genetics.
- Psychiatry--methods.
- Medical Subjects:
- Genetic Predisposition to Disease--genetics.
- Genetic Diseases, Inborn--genetics.
- Mental Disorders--genetics.
- Psychiatry--methods.
- Physical Description:
- xvi, 272 pages : illustrations ; 24 cm
- Place of Publication:
- New York : Guilford Press, [1999]
- Summary:
- This book provides a comprehensive and readable primer on the complex interplay of genetic and environmental factors in mental disorders. Rendering technical concepts accessible, and laying to rest common myths and oversimplifications, the book describes what (and how) scientists have learned about the causation and expression of such frequently encountered disorders as schizophrenia, bipolar disorder, depression, and Alzheimer disease. Clinicians and students gain the basic knowledge they need to evaluate the literature in this rapidly developing field, understand implications for treatment, and communicate genetic information to clients and families. Throughout, special attention is given to the critical ethical and professional concerns raised by emerging technologies.
- Contents:
- What Is Psychiatric Genetics 2
- Clinical Uses of Psychiatric Genetics 4
- Genes, Environment, and the Genesis of Psychopathology 7
- The Chain of Psychiatric Genetic Research 11
- Chapter 2 The Basics: Epidemiologic Foundations of Psychiatric Genetics 15
- Is a Disorder Familial?: The Case-Control Family Study 16
- Evaluating Family Studies 21
- Is the Disorder Genetic?: Twin Studies 29
- Partitioning Genetic and Environmental Sources of Illness 32
- Evaluating Twin Studies 37
- Is the Disorder Genetic?: Adoption Studies 39
- Evaluating Adoption Studies 42
- Summary: Epidemiologic Foundations of Psychiatric Genetics 43
- Chapter 3 Variations on a Theme: Causal and Clinical Heterogeneity 46
- Can We Define Genetic and Nongenetic Subtypes? 50
- Are There Genetic Variants of the Disorder? 55
- How Do We Identify Genetic Spectrum Disorders? 58
- Spectrum Conditions for Other Disorders 61
- What Are the Neurobiologic Correlates of Genetic Predisposition? 63
- Do Two or More Disorders Share Familial Causal Factors? 70
- Why Do Two Disorder Co-Occur 74
- How Do We Show Developmental Continuity Between Disorders of Children and Adults? 89
- Chapter 4 Mathematical Models of Inheritance 93
- Modes of Genetic Transmission 94
- Single-Gene Inheritance 94
- Oligogenic Inheritance 100
- Multifactoral Polygenic Inheritance 101
- Segregation Analysis: Determining the Mode of Transmission 106
- Overview of Mathematical Modeling 107
- Path Analysis 109
- Obstacles to Establishing the Mode of Inheritance 112
- Chapter 5 Molecular Genetics and Mental Illness 115
- Biologic Background 117
- DNA Markers for Linkage Analysis 124
- Statistical Methods for Linkage Analysis 126
- The Affected Pedigree Member Method of Linkage Analysis 129
- The Lod Score Method of Linkage Analysis 131
- Guidelines for Interpreting Linkage Results 133
- Examples of Linkage Analysis 134
- Association Studies 136
- Population-Based Association Studies 136
- Family-Based Association Studies 140
- The Search for Disease Mechanisms 143
- Finding Mutations That Cause Disease 143
- Types of Mutations 144
- Cytogenetic Abnormalities and Psychiatric Disorders 146
- Animal Models of Human Disorders 152
- Disease Genes and Environmental Mechanisms 155
- Chapter 6 Clinical Applications of Psychiatric Genetics 159
- Genetic Counselling for Psychiatric Disorders 160
- Stages of Genetic Counseling 160
- Implications for Diagnosis and Treatment 188
- Family-Based Diagnosis 188
- Fighting Therapeutic Nihilism 191
- Facilitating Treatment 193
- Chapter 7 The Future of Psychiatric Genetics 196
- The Promise of New Technologies 197
- Molecular Genetics: The Human Genome Project 197
- A Clinical Nosology for Psychiatric Genetics 199
- The Future of Predictive Genetic Testing 206
- Presymptomatic Genetic Testing 206
- Lessons from Predictive Testing in Huntington Disease 209
- The Future of Mental Health Treatment 213
- Early Identification and Prevention of Disorders 213
- Medical Interventions for Genetic Defects 219
- Ethical Issues for the Science and Practice of Psychiatric Genetics 222
- The Shadow of Eugenics 222
- Ethical Issues for Genetic Testing 225
- Informed Consent: The Cornerstone of Ethical Research and Practice 231
- Ethical Issues for Gene Therapy 231.
- Notes:
- Includes bibliographical references (pages 249-256) and index.
- ISBN:
- 1572304790
- OCLC:
- 40948410
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