Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding / Alan Fersht.

Format:

Book

Author/Creator:

Fersht, Alan, 1943-

Contributor:

Class of 1932 Fund.

Language:

English

Subjects (All):

Proteins--Structure.

Proteins.

Enzymes.

Enzyme kinetics.

Protein folding.

Protein Folding.

Protein Engineering.

Protein Conformation.

Medical Subjects:

Protein Folding.

Protein Engineering.

Enzymes.

Protein Conformation.

Physical Description:

xxi, 631 pages : illustrations ; 25 cm

Place of Publication:

New York : W.H. Freeman, [1999]

Contents:

1 The Three-dimensional Structure of Proteins

2 Chemical Catalysis

3 The Basic Equations of Enzyme Kinetics

4 Measurement and Magnitude of Enzymatic Rate Constants

5 The pH Dependence of Enzyme Catalysis

6 Practical Kinetics

7 Detection of Intermediates in Reactions by Kinetics

8 Stereochemistry of Enzymatic Reactions

9 Active-site-directed and Enzyme-activated Irreversible Inhibitors: Affinity Labels and Suicide Inhibitors

10 Conformational Change, Allosteric Regulation, Motors, and Work

11 Forces Between Molecules and Enzyme-Substrate Binding Energies

12 Enzyme-substrate Complementarity and the Use of Binding Energies in Catalysis

13 Specificity and Editing Mechanisms

14 Recombinant DNA Technology

15 Case Studies of Enzyme Structure and Mechanism

16 Protein Engineering

17 Protein Stability

18 Kinetics of Protein Folding

19 Folding Pathways and Energy Landscapes.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Class of 1932 Fund.

ISBN:

0716732688

OCLC:

39606488