Phosphoinositides : chemistry, biochemistry, and biomedical applications / Karol S. Bruzik, editor.

Format:

Book

Contributor:

Bruzik, K. S.

Series:

ACS symposium series ; 718.

ACS symposium series ; 718

Language:

English

Subjects (All):

Phosphoinositides--Congresses.

Phosphoinositides.

Genre:

Conference papers and proceedings.

Physical Description:

xii, 298 pages : illustrations ; 24 cm.

Place of Publication:

Washington, DC : American Chemical Society, [1999]

Summary:

This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids and features contributions from some of the leading laboratories. The chapters span three key topics: the metabolism of inositol phosphates and identification of proteins that interact with polyphosphorylated phosphatidylinositols; the mechanisms and structure of phosphatidylinositol-specific phospholipase C; and the synthesis and biological properties of analogs for phosphoinositides.

Contents:

Inositol Phosphate Metabolism and Inositol Phospholipid Binding Proteins

1. The Structural and Functional Versatility of Inositol Phosphates / James J. Caffrey, Stephen T. Safrany, Xiaonian Yang, Masako Yoshida, Stephen B. Shears 2

2. Probing Phosphoinositide Polyphosphate Binding to Proteins / Glenn D. Prestwich, Anu Chaudhary, Jian Chen, Li Feng, Bharat Mehrotra, Jirong Peng 24

3. Differential Recognition of Phosphoinositides by Actin Regulating Proteins and Its Physiological Implications / Pei-Jung Lu, Da-Sheng Wang, Keng-Mean Lin, Helen L. Yin, Ching-Shih Chen 38

4. Studies on New Ins(1,4,5)P[subscript 3] Binding Proteins with Reference to the pH Domains / Takashi Kanematsu, Hiroshi Takeuchi, Masato Hirata 55

Mechanism and Structure of Phosphatidylinositol-Specific Phospholipases C

5. Structure and Mechanism of Ca[superscript 2+]-Independent Phosphatidylinositol-Specific Phospholipases C / Dirk W. Heinz, Jurgen Wehland, O. Hayes Griffith 80

6. Characterization of the Histidine Residues of B. cereus Phosphatidylinositol-Specific Phospholipase C by NMR / Tun Liu, Margret Ryan, Frederick W. Dahlquist, O. Hayes Griffith 91

7. Mechanism of Phosphatidylinositol-Specific Phospholipase C Revealed by Protein Engineering and Phosphorothioate Analogs of Phosphatidylinositol / Robert J. Hondal, Zhong Zhao, Alexander V. Kravchuk, Hua Liao, Suzette R. Riddle, Karol S. Bruzik, Ming-Daw Tsai 109

8. Structural Analysis of the Catalysis and Membrane Association of PLC-[delta subscript 1] / L.-O. Essen, P. D. Brownlie, O. Perisic, M. Katan, R. L. Williams 121

9. Sequential Mechanism and Allosteric Activation of Phosphoinositide-Specific Phospholipase C-[delta subscript 1] / Mary F. Roberts, Yiqin Wu, Olga Perisic, Roger L. Williams, Matilda Katan 137

Synthesis and Biological Properties of Analogs of Phosphoinositides

10. Structure-Activity Relationships of Adenophostin A and Related Molecules at the 1-D-myo-Inositol 1,4,5-Trisphosphate Receptor / Barry V. L. Potter 158

11. Stereospecific Syntheses of Inositol Phospholipids and Their Phosphorothioate Analogs / Robert J. Kubiak, Xiangjun Yue, Karol S. Bruzik 180

12. Chemical Synthesis of Phosphatidylinositol Phosphates and Their Use as Biological Tools / Yutaka Watanabe 197

13. Synthesis of Phosphatidyl-myo-inositol Polyphosphates and Derivatives / Shoichiro Ozaki, Yutaka Watanabe, Takehiro Maekawa, Yuichi Higaki, Tomio Ogasawara, Xiang Zheng Kong 212

14. Syntheses of 2-Modified Phosphatidylinositol 4,5-Bisphosphates: Putative Probes of Intracellular Signaling / R. Aneja, S. G. Aneja 222

15. Membrane-Permeant, Bioactivatable Derivatives of Inositol Polyphosphates and Phosphoinositides / Carsten Schultz, Marco T. Rudolf, Hartmut H. Gillandt, Alexis E. Traynor-Kaplan 232

16. Synthesis of Inositol-Containing Glycophospholipids with Natural and Modified Structure / Alexander E. Stepanov, Vitaly I. Shvets 244

17. Inositol Phosphates: Inframolecular Physico-Chemical Studies: Correlation with Binding Properties / G. Schlewer, P. Guedat, S. Ballereau, L. Schmitt, B. Spiess 255

18. 5-Deoxy-5-fluoro-1-O-phosphatidylinositol: Evidence for the Enzymatic Incorporation of a Fraudulent Cyclitol into the Phosphatidylinositol Cycle: A Mass Spectrometric Study / David C. Baker, Stephen C. Johnson, James D. Moyer, Nancy Malinowski, Frank Tagliaferri, Albert Tuinman 271.

Notes:

Developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 214th National Meeting of the American Chemical Society, Las Vegas, Nevada, September 7-11, 1997.

Includes bibliographical references and indexes.

ISBN:

0841236283

OCLC:

39659058