The impact of stereochemistry on drug development and use / [edited by] Hassan Y. Aboul-Enein and Irving W. Wainer.

Format:

Book

Contributor:

Aboul-Enein, Hassan Y.

Wainer, Irving W.

Class of 1932 Fund.

Series:

Chemical analysis ; v. 142.

Chemical analysis ; v. 142

Language:

English

Subjects (All):

Chiral drugs.

Physical Description:

xxvii, 695 pages : illustrations ; 24 cm.

Place of Publication:

New York : Wiley, [1997]

Summary:

This book is an authoritative source of information on stereochemistry and its impact on drug development. It explores the physiological impact of chiral molecules -- molecules that can be found in "right-handed" and "left-handed" forms. It addresses how the body metabolizes chiral molecules, examines the varying effects of different chiral molecules and provides detailed evaluations of separation techniques.

Emphasizes physiological effects.-- Includes the latest regulatory issues and guidelines (US and international).

Contents:

Chapter 1 Chirality and Drug Hazards / Hassan Y. Aboul-Enein, Laila I. Abou Basha 1

Chapter 2 Stereochemistry in the Drug Development Process: Role of Chirality as a Determinant of Drug Action, Metabolism, and Toxicity / Thomas A. Baillie, Kathleen M. Schultz 21

Chapter 3 Stereochemical Aspects of Drug Metabolism / Jonathan P. Mason, Andrew J. Hutt 45

Chapter 4 Some Examples for Stereoselective Biotransformation of Drugs / Gottfried Blaschke 107

Chapter 5 Kinetics of Reactive Phase II Metabolites: Stereochemical Aspects of Formation of Epimeric Acyl Glucuronides and Their Reactivity / Hildegard Spahn-Langguth, Leslie Z. Benet, Parnian Zia-Amirhosseini, Seigo Iwakawa, Peter Langguth 125

Chapter 6 Studies on the Stereoselectivity of the Biologically Important Metabolism of Alkene-Alkene Oxide (Oxirane)-Alkanediol / Dorothee Wistuba 173

Chapter 7 Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity / Jacek Bojarski 201

Chapter 8 Ethambutol and Tuberculosis, A Neglected and Confused Chiral Puzzle / Bernard Blessington 235

Chapter 9 Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity / Stig G. Allen Mark 263

Chapter 10 The Importance of Chiral Separations in Pharmaceuticals / Sut Ahuja 287

Chapter 11 Separation of Optically Active Pharmaceuticals Using Capillary Electrophoresis / Timothy J. Ward, Karen D. Ward 317

Chapter 12 Chiral Recognition Mechanism of Polysaccharides Chiral Stationary Phases / Eji Yashima, Yoshio Okamoto 345

Chapter 13 Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds / Michael E. Swartz, Phyllis R. Brown 377

Chapter 14 Unified Enantioselective Chromatography Involving Chirasil-Dex / Volker Schurig, Sabine Mayer, Martin Jung, Markus Fluck, Hansjorg Jakubetz, Alexandra Glausch, Simona Negura 401

Chapter 15 Derivatized Cyclodextrins as Chiral Gas Chromatographic Stationary Phases and Their Potential Applications in the Pharmaceutical Industry / Weiyong Li, Thomas M. Rossi 415

Chapter 16 Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection / Ralf Buschges, Hassan Y. Aboul-Enein, Eric Martin, Peter Langguth, Hildegard Spahn-Langguth 437

Chapter 17 Circular Dichroism Spectroscopy in the Analysis of Chiral Drugs / Piera Salvadori, Carlo Rosini, Carlo Bertucci 493

Chapter 18 Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins / Carlo Bertucci, Piero Salvadori, Enrico Domenici 521

Chapter 19 Current Regulatory Guidelines of Stereoisomeric Drugs: North American, European, and Japanese Point of View / Sylvie Laganiere 545

Chapter 20 Enantioselective Analysis and the Regulation of Chiral Drugs / Michael Gross 565

Chapter 21 First Pass Phenomena: Sources of Stereoselectivities and Variabilities of Concentration-Time Profiles after Oral Dosage / Hildegard Spahn-Langguth, Leslie Z. Benet, Werner Mohrke, Peter Langguth 573

Chapter 22 Gastrointestinal Transport Processes: Potentials for Stereoselectivities at Substrate-Specific and Nonspecific Epithelial Transport Systems / Peter Langguth, Gordon L. Amidon, Elke Lipka, Hildegard Spahn-Langguth 611

Chapter 23 Preparation of Drug Enantiomers by Chromatographic Resolution on Chiral Stationary Phases / Eric Francotte 633.

Notes:

Series no. on spine 134 [sic].

"A Wiley-Interscience publication."

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Class of 1932 Fund.

ISBN:

0471596442

OCLC:

35262289