Towards prolongation of the healthy life span : practical approaches to intervention / edited by Denham Harman, Robin Holliday, and Mohsen Meydani.

Format:

Book

Contributor:

Harman, Denham.

Holliday, R. (Robin), 1932-2014.

Meydani, Mohsen.

Series:

Annals of the New York Academy of Sciences ; v. 854.

Annals of the New York Academy of Sciences ; v. 854

Language:

English

Subjects (All):

Longevity--Congresses.

Longevity.

Aging--Molecular aspects--Congresses.

Aging.

Aging--Molecular aspects.

Aging--Physiological aspects--Congresses.

Aging--Physiological aspects.

Life Expectancy.

Aged.

Medical Subjects:

Longevity.

Life Expectancy.

Aged.

Genre:

Conference papers and proceedings.

Physical Description:

xiv, 524 pages : illustrations ; 24 cm.

Place of Publication:

New York, N.Y. : New York Academy of Sciences, 1998.

Contents:

Aging: Phenomena and Theories / Denham Harman 1

Part I. Molecular and Cellular Changes with Age

Genes Involved in the Control of Cellular Proliferative Potential / Roger R. Reddel 8

Somatic Mutation and Aging / Alec Morley 20

Chromosomal Damage Rate, Aging, and Diet / Michael Fenech 23

Pluripotent Protective Effects of Carnosine, a Naturally Occurring Dipeptide / A.R. Hipkiss, J.E. Preston, D.T.M. Himsworth, V.C. Worthington, M. Keown, J. Michaelis, J. Lawrence, A. Mateen, L. Allende, P.A.M. Eagles, N. Joan Abbott 37

The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated Heat Shock on Human Fibroblasts / Suresh I. S. Rattan 54

Causes of Aging / Robin Holliday 61

Part II. Exercise and Aging

Intrinsic and Extrinsic Factors in Muscle Aging / Joseph G. Cannon 72

Age-associated Changes in the Response of Skeletal Muscle Cells to Exercise and Regeneration / Miranda D. Grounds 78

Age-associated Changes in the Innervation of Muscle Fibers and Changes in the Mechanical Properties of Motor Units / Anthony R. Luff 92

Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant Systems / Li Li Ji, Chris Leeuwenburgh, Steve Leichtweis, Mitch Gore, Russel Fiebig, John Hollander, Jeffery Bejma 102

Part III. Role of Mitochondria in Aging

Mitochondrial Aging: Open Questions / Kenneth B. Beckman, Bruce N. Ames 118

Mitochondrial DNA Mutations and Age / Takayuki Ozawa 128

Oxidative Damage and Mutation to Mitochondrial DNA and Age-dependent Decline of Mitochondrial Respiratory Function / Yau-Huei Wei, Ching-You Lu, Hsin-Chen Lee, Cheng-Yoong Pang, Yi-Shing Ma 155

Tissue-specific Distribution of Multiple Mitochondrial DNA Rearrangements during Human Aging / Sergey A. Kovalenko, George Kopsidas, Joanne Kelso, Franklin Rosenfeldt, Anthony W. Linnane 171

Influences of Caloric Restriction on Age-associated Skeletal Muscle Fiber Characteristics and Mitochondrial Changes in Rats and Mice / Connie M. Lee, Lauren E. Aspnes, Susan S. Chung, Richard Weindruch, Judd M. Aiken 182

The Effects of Dietary Restriction on Mitochondrial Dysfunction in Aging / Ritchie J. Feuers 192

The Universality of Bioenergetic Disease: Age-associated Cellular Bioenergetic Degradation and Amelioration Therapy / Anthony W. Linnane, S. Kovalenko, E.B. Gingold 202

Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl-L-Carnitine and N-tert-Butyl-[alpha]-phenyl-nitrone / Tory M. Hagen, Carol M. Wehr, Bruce N. Ames 214

Mitochondrial Free Radical Production and Aging in Mammals and Birds / Gustavo Barja 224

Oxidative Damage in the Senescence-accelerated Mouse / Akitane Mori, Kozo Utsumi, Jiankang Liu, Masanori Hosokawa 239

Roundtable Discussion: How Best to Ameliorate the Normal Increase in Mitochondrial Superoxide Formation with Advancing Age 251

Part IV. Pharmacological Intervention in Aging Processes: Focus on Oxyradicals and Molecular Mechanisms

Membrane and Receptor Modifications of Oxidative Stress Vulnerability in Aging: Nutritional Considerations / J.A. Joseph, N. Denisova, D. Fisher, B. Shukitt-Hale, P. Bickford, R. Prior, G. Cao 268

Immunohistochemical and ELISA Assays for Biomarkers of Oxidative Stress in Aging and Disease / Joelle M. Onorato, Suzanne R. Thorpe, John W. Baynes 277

Assessing the Effects of Deprenyl on Longevity and Antioxidant Defenses in Different Animal Models / Kenichi Kitani, Setsuko Kanai, Gwen O. Ivy, Maria Cristina Carrillo 291

Age-associated Memory Impairment: Assessing the Role of Nitric Oxide / Robert C. Meyer, Edward L. Spangler, Hideki Kametani, Donald K. Ingram 307

Telomeres: Influencing the Rate of Aging / Thomas von Zglinicki 318

Redox Regulation of the Caspases during Apoptosis / Mark B. Hampton, Bengt Fadeel, Sten Orrenius 328

Part V. Nutritional Intervention in Aging

Nutrition, Osteoporosis, and Aging / B.E. Christopher Nordin, Allan G. Need, Tracy Steurer, Howard A. Morris, Barry E. Chatterton, Michael Horowitz 336

The Effect of Long-term Dietary Supplementation with Antioxidants / M. Meydani, R. D. Lipman, S.N. Han, D. Wu, A. Beharka, K.R. Martin, R. Bronson, G. Cao, D. Smith, S.N. Meydani 352

B Vitamins and Homocysteine in Cardiovascular Disease and Aging / David E.L. Wilcken, Bridget Wilcken 361

Nutrition, Cancer, and Aging / Ivor E. Dreosti 371

Combined Exercise and Dietary Intervention to Optimize Body Composition in Aging / Maria A. Fiatarone Singh 378

Part VI. Antioxidants and Aging

The Biochemical, Pathophysiological, and Medical Aspects of Ubiquinone Function / Hans Nohl, Lars Gille, Katrin Staniek 394

Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin / Russel J. Reiter, Juan M. Guerrero, Joaquin J. Garcia, Dario Acuna-Castrovieio 410

Recycling and Redox Cycling of Phenolic Antioxidants / V.E. Kagan, Y.Y. Tyurina 425

The Chemistry and Biological Effects of Flavonoids and Phenolic Acids / Kevin D. Croft 435

The Antioxidant and Biological Properties of the Carotenoids / Norman I. Krinsky 443

Structural and Functional Changes in Proteins Induced by Free Radical

mediated Oxidative Stress and Protective Action of the Antioxidants N-tert-Butyl-[alpha]-phenylnitrone and Vitamin E / D. Allan Butterfield, Tanuja Koppal, Beverly Howard, Ram Subramaniam, Nathan Hall, Kenneth Hensley, Servet Yatin, Kerry Allen, Michael Aksenov, Marina Aksenova, John Carney 448

Roundtable Discussion: How Best to Ensure Daily Intake of Antioxidants (from the Diet and Supplements) That is Optimal for Life Span, Disease, and General Health 463

Synergistic Multitherapy as a Rational Strategy in Aging: Multifactorial Process / Sorin Riga, Dan Riga 477

Cell Signaling as a Major Factor of Intervention into the Aging Process / Hans Niedermuller, Alois Strasser, Gerhard Hofecker 478

Are Free Radicals a Cause of Aging? / Jose Remacle 479

A New Genetic Conception of Aging and the Possible Mechanisms of Aging Pathologies / Teimuraz Lezhava 480

The Pineal Peptide Preparation, Epithalamin, Slows Aging in Drosophila melanogaster, Mice, and Rats / V.N Anisimov, S.V. Mylnikov, V.Kh. Khavinson 481

Similar Gene Expression Patterns in Senescent and Hyperoxically Blocked Fibroblasts / Gabriele Saretzki, Thomas von Zglinicki, Bryant Villeponteau 482

Altered Gene Expression in the Brain of the Senescence-accelerated Mouse / Ryoya Takahashi, Yuki Makabe, Sataro Goto 483

Prolongation of the Healthy Life Span with Early Diagnosis of T(14;18) Translocation / I. Semsei, Gy. Szegedi, M. Zeher, I. Takacs, P. Sebok 484

Genetic Dissection of Senile Hypoactivity in Drosophila melanogaster / Christopher Driver 485

Structural Changes of Chromosomes Induced by Heavy Metal Salts during in Vivo and in Vitro Aging / Tina Jokhadze 486

Total Extent and Cellular Distribution of Mitochondrial DNA Mutations in Aging / S.A. Kovalenko, J. Kelso, G. Kopsidas, A.W. Linnane 487

Coenzyme Q[subscript 10] Treatment Improves the Tolerance of the Senescent Myocardium to Pacing Stress in the Rat / Franklin L. Rosenfeldt, Michael A. Rowland, Philip Nagley, Anthony W. Linnane 488

Response of the Human Myocardium to Hypoxia and Ischemia Declines with Age: Correlation with Increased Mitochondrial DNA Deletions / Franklin L. Rosenfeldt, Justin A. Mariani, Rouchong Ou, Salvatore Pepe, Philip Nagley, Anthony W. Linnane 489

Impairment of Mitochondrial Function in the Aging Heart: Molecular and Pharmacological Aspects / G. Paradies, G. Petrosillo, F.M. Ruggiero 491

Aluminosilicate Particulate and Beta-Amyloid in Vitro Interactions: A Model of Alzheimer Plaque Formation / Peter Evans, Charles Harrington 492

Does Extracellular Ascorbate Promote Oxidative Damage to the Aging Brain? / Maria M. Romanas, Mitchell R. Emerson, Stanley R. Nelson, Fred E. Samson, Thomas L. Pazdernik 493

Low Levels of 4977 BP-deleted Molecules of Mitochondrial DNA in the Presence of High OH[superscript 8]DG Contents in Healthy Subjects and Alzheimer's Disease Patients / A.M.S. Lezza, P. Mecocci, A. Cormio, A. Cherubini, M. Flint Beal, P. Cantatore, U. Senin, M.N.

Gadaleta 494

Correlations between Lipofuscin Accumulation and Aging Neuropathology / Dan Riga, Sorin Riga 495

Proteasome but Not Lysosomal Protease Activities Decline with Age in the Liver of Male F344 Rats / T. Hayashi, Y. Nakano, R. Takahashi, S. Goto 496

Macrophage Membrane Proteins That Recognize Carbohydrate Chains of Oxidized Erythrocytes / Masatoshi Beppu, Shigetoshi Eda, Kiyomi Kikugawa 497

Aging and Dietary Protein: Effects of Collagen and Muscle Fiber Distribution in the Rat Diaphragm / Emilio A. Jeckel-Neto, Tatiana Ribeiro da Silva, Alessandra L. Rosa, Yoshitake Ito, Tsuneko Sato, Hisashi Tauchi 498

Characterization of Age-dependent Multiple Yellow Fluorescent Components in Rat Kidney / Kiyomi Kikugawa, Masatoshi Beppu, Akihide Sato, Hiroyoshi Kasai 499

Age-dependent Effect of Estrogen on Oxidative Stress of Ovariectomy-induced Osteoporotic Bones / Se In Oh, Mee Sook Lee, Chang-Mo Kang, Young Do Koh, Kyu Hwan Kim, Eui-Ju Yeo, Sang Chul Park 500

Accelerated Aging of the Female Reproductive System in Mice following Exposure to Tobacco Smoke / C. Gary Gairola 501

Endogenous Antioxidant Defense and Lipid Peroxidation in Elderly Patients with Diabetes Mellitus / L.H. Chen, Y. Osio, J.W. Anderson 502

The Reliability of the Mitochondrial Electron-transport Membranes and Implications for Aging / V.K. Koltover 503

The Breathing Exercise, Qigong: A Traditional Exercise Approach for the Improvement of Symptoms in Aged Diabetics Through Modulation of Psychological State / Shaojin Duan, Tong Xin Tian, Ying-Jian Duan, Yen-Rong Mao, Chun-Zhi Zhang 504

Maintaining Mobility in Nursing Home Residents / Arnold H. Greenhouse, Susan O'Brien 505

Double-blind Trial of Huperzine-A (HUP) on Cognitive Deterioration in 314 Cases of Benign Senescent Forgetfulness, Vascular Dementia, and Alzheimer's Disease / Ma Young-Xing, Zhu Yue, Gu Yue-Di, Yu Zhen-Yan, Yu Sai-Mei, Ye Yong-Zhen 506

Double-blind Trial of Aniracetam on Cognitive Deterioration in 622 Cases of Benign Senescent Forgetfulness, Vascular Dementia, and Alzheimer's Disease / Ma Yong-Xing, Yu Zhen-Yan, Jin Yong-Shou, Yu Sai-Mei, Ye Yong-Zhen, Gao Zhi-Xu, Fang Yong-Sheng, Hong Zhen, Ding Zhao-Lan 508

The Relationship between the Cognitive Deterioration, Pulse Transit Time, Microcirculation, and Free Radical Metabolism in the Preaged and Aged / Ma Yong-Xing, Zhu Yue, Chen Shu-Ying, Wang Zan-Shun, Yu Zhen-Yan, Qui Zhi-Jun, Yu Sai-Mei 510

Free Radicals and Arteriosclerosis / Ma Yong-Xing, Wang Zan-Shun, Chen Shu-Ying, Zhu Han-Min, Gui Liang-Zhen, Chen Wei-Qing 511

The Age-retarding Effect of Reinhardt and Sea Cucumber Capsule (RSC) / Ma Yong-Xing, Wang Chuan-Fu, Yu Zhen-Yan, Yuan Zhao-Hui, Chun Su-Ying, Xie Hui 513

Alzheimer's Disease: A Hypothesis on Pathogenesis / Denham Harman 515

Relationship between Fatty Acid Unsaturation, Sensitivity to Lipid Peroxidation, and Maximum Life Span in the Liver of Mammals / R. Pamplona, M. Portero-Otin, D. Riba, M. Lopez-Torres, G. Baria 516

Localization in a Region of Complex I and Mechanism of the Higher Free Radical Production of Brain Nonsynaptic Mitochondria in the Short-lived Rat Than in the Longevous Pigeon / G. Baria, A. Herrero 517

Heart and Brain OXO[superscript 8]dG in the Genomic DNA of Rats and Pigeons and Maximum Longevity / A. Herrero, G. Baria 518

Cell Proliferation Restriction: Is It the Primary Cause of Aging? / Alexander N. Khokhlov 519

Study of "Stationary Phase Aging" of Cultured Cells under Various Types of Proliferation Restriction / Serge S. Akimov, Alexander N. Khokhlov 520.

Notes:

Includes bibliographical references and index.

ISBN:

1573311081

157331109X

OCLC:

39922084