Stroke therapy : basic, preclinical, and clinical directions / edited by Leonard P. Miller.

Format:

Book

Contributor:

Miller, Leonard P., 1946-

Language:

English

Subjects (All):

Cerebrovascular disease--Treatment.

Cerebrovascular disease.

Cerebrovascular disease--Pathophysiology.

Cerebrovascular Disorders--therapy.

Medical Subjects:

Cerebrovascular Disorders--therapy.

Physical Description:

xvi, 436 pages : illustrations ; 25 cm

Place of Publication:

New York : Wiley-Liss, [1999]

Summary:

A comprehensive look at the pharmacological basis of novel stroke therapy. This book covers three major areas: Basic Science -- stroke-mediated cell damage; Preclinical Studies -- major pharmacotherapeutic approaches to date; and Clinical Trials -- history, overview, and clinical design. The book is an unusually well-integrated effort by basic scientists, clinicians, and representatives of the pharmaceutical industry.

Contents:

1. Cellular and Vascular Pathophysiology of Stroke / Jody Vaughn, Ross Bullock 3

2. Preclinical Models of Stroke / Colin A. Campbell, A. Jackie Hunter 39

II. Preclinical Studies 63

3. Preclinical Studies of Glutamate Receptor Antagonists for the Treatment of Cerebral Ischemia / Daniel L. Small, Paul Morley, Alastair M. Buchan 65

4. [alpa]-Aminobutyric Acid Agonists for Neuroprotection / Patrick D. Lyden 101

5. Adenosine in Ischemic Brain Injury / Leonard P. Miller 131

6. Sodium and Calcium Channel Modulators in Stroke Therapy / Michael Spedding 157

7. Intracellular Events Associated with Cerebral Ischemia / Dwaine F. Emerich, Raymond T. Bartus 195

8. Nitric Oxide: Cellular and Molecular Pathways in Stroke / Kenneth Maiese 219

9. Free Radicals in Stroke / Edward D. Hall 245

10. Cellular Inflammation in Experimental Ischemic Stroke / Julio H. Garcia, Leonard Pantoni 271

11. Apoptosis: Dna Damage and Repair in Stroke / Philip K. Liu, Winifred J. Hamilton, Chung Y. Hsu 299

12. Reparative Approaches: Growth Factors and Other Pharmacological Treatments / Steven C. Cramer, Seth P. Finklestein 321

III. Clinical Direction 337

13. Clinical Trials for Stroke: Design Considerations / David G. Sherman, Oscar Benavente 339

14. Thrombolytic Treatment of Thrombotic Stroke / Gregory J. del Zoppo 355

15. Perioperative Stroke, Encephalopathy, and Cns Dysfunction / Dennis Thomas Mangano, Christina Mora Mangano 383

16. Stroke: Present and Future Therapy / Justin A. Zivin, Leonard P. Miller 401.

Notes:

Includes bibliographical references and index.

ISBN:

0471183474

OCLC:

39094213