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The identification of orthodenticle-interacting genes in drosophila melanogaster / Yuebing Li.
LIBRA Thesis L693 1998
Available from offsite location
LIBRA Diss. POPM1998.233
Available from offsite location
- Format:
- Book
- Manuscript
- Microformat
- Thesis/Dissertation
- Author/Creator:
- Li, Yuebing.
- Language:
- English
- Subjects (All):
- Penn dissertations--Neuroscience.
- Neuroscience--Penn dissertations.
- Neurosciences.
- Academic Dissertations as Topic.
- Medical Subjects:
- Neurosciences.
- Academic Dissertations as Topic.
- Local Subjects:
- Penn dissertations--Neuroscience.
- Neuroscience--Penn dissertations.
- Physical Description:
- xii, 127 pages : color illustrations ; 29 cm
- Production:
- 1998.
- Summary:
- The goal of the studies described in this thesis is to investigate the mechanism of adult head development in Drosophila melanogaster. Like the thoracic appendages, adult head structures are derived from the imaginal discs. Although the mechanisms that specify the thoracic appendages have been studied in detail, adult head development remains poorly understood.
- In this study, I focused on the role of the homeobox gene orthodenticle (otd) in head development. otd is an essential regulatory gene that specifies the formation of the dorsal head capsule. To understand the molecular mechanism by which otd specifies the dorsal head, I searched for mutations that interact with otd in adult head formation. Among known mutations, genetic interactions were demonstrated between otd and hedgehog (hh), engrailed (en) and cubitus interruptus (ci). A genetic screen for novel mutations revealed a total of 17 loci that interact with otd in adult head development. One of the mutations identified was in the Grunge (Gug) gene. Further analysis demonstrated that Gug is also a novel component of the Notch (N) signaling pathway.
- Finally, a genetic and molecular analysis of an interacting gene in the 31E region was initiated. This enhancer mutation was shown to correspond to a previously defined complementation group in this region. Preliminary molecular analysis was performed to localize this gene.
- Notes:
- Adviser: Robert Finkelstein.
- Thesis (Ph.D. in Neuroscience) -- University of Pennsylvania, 1998.
- Includes bibliographical references.
- Local Notes:
- University Microfilms order no.: 98-40214.
- OCLC:
- 187472952
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