Cocaine abuse : behavior, pharmacology, and clinical applications / Stephen T. Higgins, Jonathan L. Katz.

Format:

Book

Author/Creator:

Higgins, Stephen T.

Contributor:

Katz, Jonathan L.

Language:

English

Subjects (All):

Behavior--drug effects.

Cocaine.

Cocaine--pharmacology.

Cocaine-Related Disorders--therapy.

Medical Subjects:

Behavior--drug effects.

Cocaine.

Cocaine--pharmacology.

Cocaine-Related Disorders--therapy.

Physical Description:

xxiv, 445 pages : illustrations ; 24 cm

Place of Publication:

San Diego : Academic Press, [1998]

Summary:

Cocaine abuse remains a major public health problem both in the U.S. and abroad. Since the 1970s, cocaine abuse has been on the rise and a vast amount of research has been directed toward understanding the mechanisms of cocaine addition, the pharmacology of cocaine, and the most effective means of treatment.

Cocaine Abuse provides in-depth, up-co-date summary reviews on major themes in cocaine research by the leading cocaine researchers. The book presents a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the basic research laboratory through the clinical and policy arenas. Included are discussions of genetic and environmental vulnerability to addiction, the effect of cocaine on the brain, central nervous system, and behavior in general, cocaine tolerance, reinforcing functions, pharmacological mechanisms, and treatment settings and successes.

Contents:

Basic pharmacological mechanisms of cocaine

Neuroanatomical bases of the reinforcing stimulus effects of cocaine

Behavioral pharmacology of cocaine and the determinants of abuse liability

Behavioral-environmental determinants of the reinforcing functions of cocaine

Tolerance and sensitization to cocaine: an integrated view

Preclinical evaluation of pharmacotherapies for cocaine abuse

Prenatal exposure to cocaine

Cocaine self-administration research: implications for rational pharmacotherapy

Evaluation of potential pharmacotherapies: response to cocaine challenge in the human laboratory

Controlled laboratory studies on the effects of cocaine in combination with other commonly abused drugs in humans

Cocaine effects on brain function

Contribution of genetic factors in cocaine and other drug abuse

Vulnerability to cocaine abuse

Treating cocaine abuse: what does research tell us?

Treatment of cocaine abuse in methadone maintenance patients

Relapse to cocaine use

Cocaine legalization: designing the experiments.

Notes:

Includes bibliographical references and index.

ISBN:

0123473608

OCLC:

39902628