Molecular biology of B-cell and T-cell development / edited by John G. Monroe and Ellen V. Rothenberg.

Format:

Book

Contributor:

Monroe, John Gordon, 1953-

Rothenberg, Ellen V.

Alumni and Friends Memorial Book Fund.

Series:

Contemporary immunology

Language:

English

Subjects (All):

T-Lymphocytes.

B-Lymphocytes.

Hematopoietic Stem Cells.

B cells.

T cells.

Hematopoietic stem cells.

Medical Subjects:

T-Lymphocytes.

B-Lymphocytes.

Hematopoietic Stem Cells.

Physical Description:

xiv, 587 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [1998]

Summary:

This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

0896035360

OCLC:

38426117