Nerve and muscle / R.D. Keynes and D.J. Aidley.

Format:

Book

Author/Creator:

Keynes, R. D.

Contributor:

Aidley, David J.

Language:

English

Subjects (All):

Myoneural junction.

Neuromuscular transmission.

Muscle contraction.

Muscles--physiology.

Nervous System Physiological Phenomena.

Medical Subjects:

Muscles--physiology.

Nervous System Physiological Phenomena.

Physical Description:

viii, 181 pages : illustrations ; 23 cm

Edition:

Second edition.

Place of Publication:

Cambridge ; New York : Cambridge University Press, 1991.

Contents:

1. Structural organization of the nervous system. Nervous systems. The anatomy of a neuron. Non-myelinated nerve fibres. Myelinated nerve fibres

2. Resting and action potentials. Electrophysiological recording methods. Intracellular recording of the membrane potential. Extracellular recording of the nervous impulse. Excitation

3. The ionic permeability of the nerve membrane. Structure of the cell membrane. Distribution of ions in nerve and muscle. The genesis of the resting potential. The Donnan equilibrium system in muscle. The active transport of ions

4. Membrane permeability changes during excitation. The impedance change during the spike. The sodium hypothesis. Voltage-clamp experiments. Patch-clamp studies

5. The molecular structure and functioning of voltage-gated ionic channels. cDNA sequencing studies. The primary structure of the sodium channel. The sodium gating current. Models of the sodium channel. Other voltage-gated channels. The ionic selectivity of voltage-gated channels

6. Cable theory and saltatory conduction. The spread of potential changes in a cable system. Saltatory conduction in myelinated nerves. Factors affecting conduction velocity. Factors affecting the threshold for excitation. After-potentials

7. Neuromuscular transmission. The neuromuscular junction. Chemical transmission. Postsynaptic responses. Presynaptic events

8.

Notes:

Includes bibliographical references ([page 171]-177) and index.

ISBN:

0521410428

9780521410427

0521422558

9780521422550

OCLC:

25204483

Online:

Publisher description