Triple-helical nucleic acids / Valery N. Soyfer, Vladimir N. Potaman.

Format:

• Book

Author/Creator:

• Soĭfer, Valeriĭ, author.
• Potaman, Vladimir N., author.

Contributor:

• Springer (Firm), publisher.
• Best-set Typesetter Ltd., compositor.
• Braun-Brumfield, Inc., printer.
• Mark B. Adams Emergence of Modern Science Collection (University of Pennsylvania)

Language:

English

Subjects (All):

• DNA.

Penn Provenance:

• Adams, Mark B., (former owner) (inscription) (Adams copy)
• Soĭfer, Valeriĭ (autograph) (Adams copy)

Physical Description:

xiv, 360 pages : illustrations ; 25 cm

Manufacture:

Ann Arbor : Braun-Brumfield, Inc.

Place of Publication:

New York : Springer, 1996.

Summary:

The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Contents:

• 1. The Discovery of Triple-Stranded Nucleic Acids
• 2. Methods of Triplex Study
• 3. General Features of Triplex Structures
• 4. Triplex Recognition
• 5. The Forces Participating in Triplex Stabilization
• 6. In Vivo Significance of Triple-Stranded Nucleic Acid Structures
• 7. Possible Spheres of Application of Intermolecular Triplexes.

Notes:

• "©1996 Springer-Verlag New York, Inc."--verso of title page.
• "Typeset by Best-set Typesetter Ltd., Hong Kong"--verso of title page.
• "Printed and bound by Braun-Brumfield, Inc., Ann Arbor, MI"--verso of title page.
• Includes bibliographical references (pages 285-346) and index.

Local Notes:

• Kislak Center copy gifted by Dr. Mark B. Adams in 2018.
• Kislak Center copy has inscription to Dr. Adams from Valery Soyfer.

ISBN:

0387944958

OCLC:

32273525