Pharmacokinetics : regulatory, industrial, academic perspectives / edited by Peter G. Welling, Francis L.S. Tse.

Format:

Book

Contributor:

Welling, Peter G.

Tse, Francis L. S.

Series:

Drugs and the pharmaceutical sciences ; v. 67.

Drugs and the pharmaceutical sciences ; v. 67

Language:

English

Subjects (All):

Pharmacokinetics.

Medical Subjects:

Pharmacokinetics.

Physical Description:

xi, 512 pages : illustrations ; 24 cm.

Edition:

Second edition.

Place of Publication:

New York : M. Dekker, [1995]

Summary:

Offering a unique, multidisciplinary approach, this state-of-the-art Second Edition of Pharmacokinetics details the rapidly changing role that clinical and nonclinical pharmacokinetics and drug metabolism play in the discovery and development of drug therapies -- emphasizing often overlooked regulatory, scientific, and economic issues.

Contents:

1. Principles of the Good Laboratory Practice Regulations Applied to Pharmacokinetics / Dexter S. Goldman 1

2. Methods to Assess Absorption in Drug Discovery / Karen Habucky 21

3. Drug Delivery Systems: Effects of Pharmacokinetics on Design, Evaluation, and Production / C. T. Rhodes 39

4. Peptide and Protein Drug Delivery / Vincent H. L. Lee 59

5. Membrane Transport / Ernest M. Wright 89

6. Blood-Brain Barrier Permeability: Pharmacological Implications with Special Emphasis on Peptides / William A. Banks, Abba J. Kastin 119

7. Modeling of Relationships Between Pharmacokinetics and Pharmacodynamics / Meindert Danhof, Jaap W. Mandema 139

8. Spatial Imaging of Radioactivity in Animal Tissues and Organs / Alain Schweitzer 175

9. Recent Developments in Drug Metabolism Methodology / Roger N. Hayes, William F. Pool, Michael W. Sinz, Thomas F. Woolf 201

10. Hepatic Microsomes and Heterologous Expression Systems as In Vitro Models for Human Drug Metabolism / Thomas Kronbach 235

11. Integration of Pharmacokinetics into Drug Discovery and Development: The Alternative Approaches / Peter G. Welling 261

12. Pharmacokinetics in Drug Discovery and Development: Nonclinical Studies / Francis L. S. Tse 281

13. Pharmacokinetics in Drug Discovery and Development: Clinical Studies / Horst F. Schran, James M. Jaffe 335

14. Population Pharmacokinetics and Pharmacodynamics / Jaap W. Mandema 411

15. Bioavailability and Bioequivalence of Oral Controlled-Release Products: A Regulatory Perspective / Henry J. Malinowski, James D. Henderson 451

16. Statistical Considerations for Bioavailability/Bioequivalence Studies / Lianng Yuh 479.

Notes:

Includes bibliographical references and index.

ISBN:

0824793781

OCLC:

31866881