Hematopoiesis : long-term effects of chemotherapy and radiation on hemopoiesis / edited by Nydia G. Testa, Robert Peter Gale.

Format:

Book

Contributor:

Testa, Nydia G., 1938-

Gale, Robert Peter.

Series:

Hematology (New York, N.Y.) ; v. 8.

Hematology ; v. 8

Language:

English

Subjects (All):

Bone marrow--Effect of drugs on.

Bone marrow.

Bone marrow--Effect of radiation on.

Antineoplastic agents--Toxicology.

Antineoplastic agents.

Cancer--Chemotherapy--Complications.

Cancer.

Cancer--Radiotherapy--Complications.

Radiotherapy--adverse effects.

Drug-Related Side Effects and Adverse Reactions.

Hematopoiesis--radiation effects.

Hematopoiesis--drug effects.

Medical Subjects:

Radiotherapy--adverse effects.

Drug-Related Side Effects and Adverse Reactions.

Hematopoiesis--radiation effects.

Hematopoiesis--drug effects.

Physical Description:

xvi, 413 pages : illustrations ; 24 cm.

Place of Publication:

New York : M. Dekker, [1988]

Summary:

Cytotoxic injury to the bone marrow from drugs, chemicals, and radiation is an important problem. This reference critically assesses the implications of bone marrow damage by analyzing mechanisms of myelosuppression, possible mutagenic action, capacity to induce chromosome abnormalities, and effects on the immune system and other tissues. Hematopoiesis places clinical and experimental observations in the context of cell biology ... evaluates the effects of treatment, disease evolution, and the induced proliferative stress on the hemopoietic system ... concentrates on hemopoiesis within a clinical framework relating to immunology, cytogenetics, and leukemogenesis ... presents the subject in a logical sequence from fundamentals to future directions for research ... and looks at new research approaches to the therapy of malignancies. Including some 1,200 citations of pertinent literature plus many drawings, tables, and photographs, Hematopoiesis serves as an indispensable resource for hematologists, oncologists, cell and molecular biologists, immunologists, internists, radiation therapists, and bone marrow transplantation specialists.

Contents:

1. The Hemopoietic System: Structure and Regulation / Brian I. Lord, Nydia G. Testa 1

II. The Structure of Hemopoiesis 3

III. Structure of the Stem Cell Population 7

IV. Regulation of Stem Cells 7

V. Regulation of Progenitor Cells 12

VI. Microarchitecture of Hemopoietic Tissue 17

2. Hemopoietic Microenvironments / Dov Zipori 27

II. Exchange of Information Among Neighboring Hemopoietic Cells 28

III. Regulation of Hemopoiesis by Stromal Cells 36

3. Myelosuppressive Effects of Antineoplastic Chemotherapy / Robert Peter Gale 63

II. Mechanisms of Myelosuppression 64

III. Kinetics of Myelosuppression 66

IV. Evaluation of Myelosuppression 68

V. Future Directions 69

4. Long-Term Bone Marrow Damage After Cytotoxic Treatment: Stem Cells and Microenvironment / Nydia G. Testa, Jolyon H. Hendry, Graham Molineux 75

II. Stem Cell Damage 76

III. Environmental Damage 81

IV. Evaluation of Long-Term Damage 83

5. Long-Term Bone Marrow Damage After Irradiation / William H. Knospe 93

I. Experimental Delayed Effects of Radiation on Bone Marrow in Animals 93

II. Delayed Effects of Radiation on the Bone Marrow in Humans 111

III. Overview of Delayed Effects of Radiation Injury on Hemopoietic Tissues 119

6. Drugs and Chemicals as Agents of Bone Marrow Failure / Neal S. Young 131

I. Clinical Observations 131

III. Pathogenic Mechanisms 142

IV. Conclusion: Anomalies 147

7. Induced Chromosome Damage After Irradiation and Cytotoxic Drugs / Niel Wald, Mary K. Conner 159

II. Cytogenetic Studies in Peripheral Blood Lymphocytes 159

III. Long-Term Cytogenetic Effects Associated with Cytostatic Therapy-Related Leukemia 180

8. Mutational Effects of Radiotherapy and Chemotherapy / Alexander A. Morley 203

II. Experimental Studies 204

III. Clinical Studies 209

IV. Molecular Changes 211

V. Consequences of Mutagenesis 213

9. Long-Term Damage to the Immune System After Irradiation / Elizabeth Naparstek, Shimon Slavin 217

II. The Effect of Ionizing Radiation on Tissues 218

III. The Immune System 219

IV. The Response of the Immune System to Irradiation 220

V. Delayed Effects of Irradiation on the Immune Function in Humans 223

10. Considerations of Long-Term Radiation Injury in Nonhemopoietic Tissues / Jolyon H. Hendry 247

II. Tissue Renewal 248

III. Temporal Expression of Injury 249

IV. Dose-Response Curves 251

V. Dose Fractionation and Dose Rate 253

VI. Lung 256

VII. Testis 262

VIII. Ovary 266

IX. Eye 267

X. Thyroid 268

XI. Growth Retardation 269

11. Long-Term Bone Marrow Damage After Treatment for Acute Lymphoblastic Leukemia / Nydia G. Testa, Manju Bhavnani, Andrew Will, Patricia H. Morris Jones 279

II. Studies of Progenitor Cells 280

III. Studies of Stromal Cells 280

IV. Evaluation of Residual Defects 284

12. Long-Term Bone Marrow Damage After Acute Nonlymphocytic Leukemia / Alan M. Miller, Roy Samuel Weiner 289

I. Current Trends in Therapy 289

II. Effects of Commonly Used Agents on Hemopoietic Cells 290

III. Progenitor Cell Assays in Leukemic Patients 292

IV. Etiology of Residual Defects 297

13. Long-Term Bone Marrow Damage After Treatment for Lymphomas / Claude Parmentier, N. Morardet, Maurice Tubiana 301

I. Long-Term Bone Marrow Damage Induced by Radiotherapy 301

II. Long-Term Bone Marrow Damage Induced by Chemotherapy 310

14. Long-Term Hemopoietic Damage After Cytotoxic Drug Therapy for Solid Tumors / Hans-Peter E. Lohrmann, Wolfgang Schreml 325

II. The Stem Cell Compartment 325

III. Effects of Cytotoxic Drugs on Stem Cells 326

IV. Experimental Long-Term Damage 328

V. Persistent Damage in Patients 328

VI. Evaluation of the Persistent Damage 334

15. Hemopoietic Engraftment and Differentiation After Bone Marrow Transplantation / Stephen G. Emerson, Robert Peter Gale 339

II. In Vitro Analysis of Human Hemopoietic Stem Cell Differentiation 340

III. Experimental Analysis of Engraftment-Stem Cells, Microenvironment, and Genetic Resistance 343

IV. Hemopoiesis Following Bone Marrow Transplantation in Humans 345

V. T Cell Depletion and Graft Failure 347

VI. Future Directions 349

16. The Origin of Bone Marrow Stroma After Transplantation: Implications for Graft Failure / Donna Przepiorka, Beverly Torok-Storb, Paul J. Simmons 357

II. Origins of Stromal Cells After Transplantation 358

III. Implications for Graft Failure 361

17. Conditions Affecting the Growth of Hemopoietic Progenitors After Bone Marrow Transplantation / Hans A. Messner, Kazuo Yamasaki 377

II. Characterization of Hemopoiesis After Bone Marrow Transplantation 377

III. Influence of the Bone Marrow Transplant Inoculum 381

IV. Influence of Host Parameters 382

V. Support of Megakaryocyte Growth in Culture 383

18. Recent Advances in the Knowledge of the Hemopoietic System: Possible Ways of Correcting Long-Term Damage / T. Michael Dexter 389

II. Development of Lineage- or Stage-Specific Cytotoxic Agents 390

III. Biological Response Modifiers: Their Role in Treatment 396

19. Bone Marrow Function: Recent Progress and Future Directions / Nydia G. Testa, Robert Peter Gale 403

I. Growth Regulators: Factors and Cells 403

II. Immunological Alterations 405

III. Secondary Malignancies 405

IV. New Therapeutic Approaches 405.

Notes:

Includes bibliographical references.

ISBN:

082477938X

OCLC:

17548783